Cytotoxicity against cholangiocarcinoma and HepG2 cell lines of lignan derivatives from Hernandia nymphaeifolia

AbstractTwelve lignan derivatives were synthesized from deoxypodophyllotoxin isolated fromHernandia nymphaeifolia. Cytotoxicity evaluation against cholangiocarcinoma, KKU-100, and HepG2 cell lines showed that compounds3,9,10, and13 exhibited stronger cytotoxicity than the starting material,1, with IC50 ranging from 0.42 to 2.01  μM. Compound10 displayed interesting activity by showing IC50 values of 0.75 and 0.46  μM against KKU-100 and HepG2 cell lines, respectively. From these observation,10 seems to be useful as a lead compound for the development of anticancer agents.
Source: Medicinal Chemistry Research - Category: Chemistry Source Type: research