Bone Marrow as a Source of Cells for Paroxysmal Nocturnal Hemoglobinuria Detection.

Conclusions: PNH clone sizes measured in mature BM leukocytes and in PB are comparable, making BM suitable for PNH assessment. We further demonstrate that commonly used reagents (not FLAER or CD55/CD59) can reliably identify abnormalities of BM neutrophils and monocytes consistent with PNH cells.
PMID: 29982419 [PubMed - as supplied by publisher]

Source: American Journal of Clinical Pathology - July 5, 2018 Category: Pathology Authors: Dulau-Florea AE, Young NS, Maric I, Calvo KR, Dunbar CE, Townsley DM, Winkler T, Monreal M, Jiang C, Jordan EK, Braylan RC Tags: Am J Clin Pathol Source Type: research