Do we need to adopt antifungal stewardship programmes

This journal article concludes that the presence of a multidisciplinary team, including an infection control specialist and a clinical pharmacist, would limit the prescription of advanced antifungal agents as empirical therapy. The authors state that this team would control the de-escalation process —where applicable—leading to a reduction in costs and, probably, a decrease in the emergence of resistant Candida species. These facts contribute to the broader discussion on the adoption of antifungal stewardship programmes.
Source: Current Awareness Service for Health (CASH) - Category: Consumer Health News Source Type: news

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Publication date: Available online 23 March 2019Source: Catalysis TodayAuthor(s): Murcia, M. Serrano-Arnaldos, S. Ortega-Requena, F. Máximo, J. Bastida, M.C. MontielAbstractBiocatalytic synthesis of ethylhexyl palmitate and ethylhexyl stearate as natural alternatives of cyclomethicone has been studied. In this work the esters have been obtained with two commercial enzymes: Novozym®435 and Novozym®40086 in a “solvent free” system. Operational conditions have been optimized using experimental design and response surface methodology. In the optimum reaction conditions conversion values were higher t...
Source: Catalysis Today - Category: Chemistry Source Type: research
Publication date: Available online 23 March 2019Source: Toxicology ReportsAuthor(s): Rehab M. Abdel-Megeed, Mai O. Kadry, Dalia B. Fayed, Abdel-Hamid Z. Abdel-HamidABSTRACTThe expedient fungi Candida albicans (C. albicans) is able to thrive in many host niches including blood stream, skin, mucosal surfaces, and different body organs. Herein, the assessment of novel synthesized pyrimidine derivatives as anti fungal agent was investigated. Female albino mice were injected intraperitoneally by C. albicans (1.5 × 106 CFU). infected Mice then subjected to treatment with two different doses which was low (50&...
Source: Toxicology Reports - Category: Toxicology Source Type: research
Publication date: Available online 22 March 2019Source: International Journal of PharmaceuticsAuthor(s): Nawinda Chinatangkul, Sukannika Tubtimsri, Danuch Panchapornpon, Prasert Akkaramongkolporn, Chutima Limmatvapirat, Sontaya LimmatvapiratAbstractDue to their ultrafine network structures, electrospun nanofibres have been potentially used for wound application. In order to develop a desired wound dressing material, shellac (SHL) was blended with polyvinyl pyrrolidone (PVP). Monolaurin (ML), which is a natural antimicrobial lipid, was incorporated into the SHL-PVP blended fibres to prevent delayed wound healing resulting f...
Source: International Journal of Pharmaceutics - Category: Drugs & Pharmacology Source Type: research
ConclusionThe denture cleaning device may be suitable for use by the elderly to clean dentures without side effects caused by the misuse of chemical cleanser.
Source: Journal of Dental Sciences - Category: Dentistry Source Type: research
In this study, we established a co-culture assay in which an azole-resistant Candida albicans strain was mixed with a susceptible strain labeled with green fluorescent protein to mimic in vivo conditions and screen for antifungal drugs. Fluconazole was used as a positive control to verify the validity of this co-culture assay. Five natural molecules exhibited antifungal activity against both susceptible and resistant C. albicans. Two of these compounds, retigeric acid B (RAB) and riccardin D (RD), preferentially inhibited C. albicans strains in which the efflux pump MDR1 was activated. This selectivity was attributed to gr...
Source: Chinese Journal of Natural Medicines - Category: Complementary Medicine Source Type: research
CONCLUSIONS: PDL and C. albicans antigen injection are safe and effective treatment alternatives for genital warts. PDL yielded better frequencies of clearance, but C. albicans antigen has additional advantages, including a single injection site and treating distant and internal mucosal uninjected warts, which are usually difficult to treat. PMID: 30901065 [PubMed - in process]
Source: Acta Dermatovenerologica Alpina, Panonica, et Adriatica - Category: Dermatology Tags: Acta Dermatovenerol Alp Pannonica Adriat Source Type: research
Conclusions There is some variation in the results according to the sampling site, which may be overcome by collecting 2 samples (anterior fornix and lower third of the vagina).
Source: Journal of Lower Genital Tract Disease - Category: OBGYN Tags: Benign Vulvovaginal Disorders Source Type: research
iano Simone Colorectal cancer (CRC) poses a formidable challenge in terms of molecular heterogeneity, as it involves a variety of cancer-related pathways and molecular changes unique to an individual’s tumor. On the other hand, recent advances in DNA sequencing technologies provide an unprecedented capacity to comprehensively identify the genetic alterations resulting in tumorigenesis, raising the hope that new therapeutic approaches based on molecularly targeted drugs may prevent the occurrence of chemoresistance. Regulation of the transcription factor FOXO3a in response to extracellular cues plays a fundame...
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Review Source Type: research
Publication date: Available online 21 March 2019Source: Microbial PathogenesisAuthor(s): Bibi Khadija, Aqsa Abbasi, Sadia Khan, Meera Nadeem, Lal Badshah, Rani FaryalAbstractObjectiveThe aim of the current study was to investigate pathogenic Candida spp. Colonization in oral cavity of postpartum females and its association with adverse pregnancy outcomes (APOs) and dental issues.MethodsSaliva samples and clinico-demographic data were collected from 267 postpartum females along with 54 non-pregnant females (Jan 2016–March 2018). Isolation of Candida was carried out by using standard microbiological methods and differe...
Source: Microbial Pathogenesis - Category: Infectious Diseases Source Type: research
This study has thus proved the advantages of the zwitterionic polymer-coated porous carrier for lipase immobilization and its potential for further development in various enzyme immobilizations.
Source: Chinese Journal of Chemical Engineering - Category: Chemistry Source Type: research
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