New Society for Endocrinology Clinical Guidance published

The Society for Endocrinology’s Clinical Committee has produced two new Clinical Guidance documents: a clinical guidance for the inpatient management of cranial diabetes insipidus, and an emergency guidance for the acute management of the endocrine complications of checkpoint inhibitor therapy. These documents are for health professionals and aim to provide guidance to adequately assess and manage the patient. TheEndocrine Emergency Guidance for the acute management of the endocrine complications of checkpoint inhibitor therapy is the first specialty-specific guidance with endocrinology, oncology and acute medicine input.TheEndocrine Guidance for inpatient management of cranial diabetes insipidus  (CDI) offers treatment pathways for patients with known CDI admitted to hospital. Following these guidelines is essential for the safe management of patients with CDI.We would appreciate your help to publicise these documents to ensure that they are available widely throughout the UK.For more information, pleasecontact us.
Source: Society for Endocrinology - Category: Endocrinology Source Type: news

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ConclusionsWe present a rare case of a patient with diabetes insipidus and cerebral salt wasting syndrome, who was successfully treated. Hyponatremia in a patient with diabetes insipidus may erroneously be interpreted as inadequate diabetes insipidus control or as syndrome of inappropriate antidiuretic hormone secretion, leading to therapeutic errors. Thus, all clinical and analytical data should be evaluated together for early and correct diagnosis.
Source: Journal of Medical Case Reports - Category: General Medicine Source Type: research
Lithium is the gold-standard treatment for bipolar disorder, is highly effective in treating major depressive disorder, and has anti-suicidal properties. However, clinicians are increasingly avoiding lithium l...
Source: BMC Psychiatry - Category: Psychiatry Authors: Tags: Study protocol Source Type: research
Authors: Miao C, Zhang L, Sun M, Ma C Abstract A 3 years old boy was hospitalized with a month's history of polydipsia, polyuria and low fever. There was no relevant family history. This is a rare case of Langerhans cell histiocytosis (LCH) with both bone and pituitary infiltration shown on the technetium-99m methylene diphosphonate (99mTc-MDP) scan and brain magnetic resonance imaging (MRI). Sagittal and coronal T1-weighted images on MRI showed the typical lack of high signal intensity of the posterior pituitary which corresponded to the central signs of diabetes insipidus (DI). The diagnosis of LCH was suspected ...
Source: Hellenic Journal of Nuclear Medicine - Category: Nuclear Medicine Tags: Hell J Nucl Med Source Type: research
CONCLUSION: p.H80Y mutation can obviously cause inappropriate folding of the protein. Therefore, the pathway of water homeostasis via AVPR2 and AVP can be improper and it can be the reason of DI. We suggest that future functional investigations of the H80Y mutation may provide a basis for understanding the pathophysiology of the NDI. PMID: 29991464 [PubMed - as supplied by publisher]
Source: JCRPE Journal of Clinical Research in Pediatric Endocrinology - Category: Endocrinology Tags: J Clin Res Pediatr Endocrinol Source Type: research
Stine Julie Tingskov, Tae-Hwan Kwon, J ørgen Frøkiær, Rikke Nørregaard
Source: Frontiers in Physiology - Category: Physiology Source Type: research
Congenital adrenal hyperplasia (CAH) due to 21-hydroxylase deficiency (21OHD) is an autosomal recessive disorder caused by mutations in the CYP21A2. Congenital nephrogenic diabetes insipidus (NDI) is a rare X-lin...
Source: BMC Medical Genetics - Category: Genetics & Stem Cells Authors: Tags: Case report Source Type: research
ConclusionsEosinophilic granuloma was the most frequently encountered orbital histiocytic lesion in our series. Eosiophilic granuloma usually responded well to subtotal tumor excision, bone curettage, and intraorbital corticosteroid injections. Systemic chemotherapy was used in cases with full thickness bone destruction and adjacent dural enhancement in an effort to prevent the development of central nervous system disease.
Source: Saudi Journal of Ophthalmology - Category: Opthalmology Source Type: research
Authors: Zenimaru Y, Yamada M, Suzuki J, Konoshita T PMID: 29984760 [PubMed - as supplied by publisher]
Source: Internal Medicine - Category: Internal Medicine Tags: Intern Med Source Type: research
Antidiuretic hormone (ADH) is responsible for regulating the body ’s fluid balance. Doctors can use an ADH test to help diagnose underlying conditions that cause fluid and electrolyte imbalances, such as diabetes insipidus. In this article, learn about the test and the potential causes of high and low levels of ADH.
Source: Health News from Medical News Today - Category: Consumer Health News Tags: Medical Devices / Diagnostics Source Type: news
ConclusionsEosinophilic granuloma was the most frequently encountered orbital histiocytic lesion in our series. Eosiophilic granuloma usually responded well to subtotal tumor excision, bone curettage, and intraorbital corticosteroid injections. Systemic chemotherapy was used in cases with full thickness bone destruction and adjacent dural enhancement in an effort to prevent the development of central nervous system disease.
Source: Saudi Journal of Ophthalmology - Category: Opthalmology Source Type: research
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