New Society for Endocrinology Clinical Guidance published

The Society for Endocrinology’s Clinical Committee has produced two new Clinical Guidance documents: a clinical guidance for the inpatient management of cranial diabetes insipidus, and an emergency guidance for the acute management of the endocrine complications of checkpoint inhibitor therapy. These documents are for health professionals and aim to provide guidance to adequately assess and manage the patient. TheEndocrine Emergency Guidance for the acute management of the endocrine complications of checkpoint inhibitor therapy is the first specialty-specific guidance with endocrinology, oncology and acute medicine input.TheEndocrine Guidance for inpatient management of cranial diabetes insipidus  (CDI) offers treatment pathways for patients with known CDI admitted to hospital. Following these guidelines is essential for the safe management of patients with CDI.We would appreciate your help to publicise these documents to ensure that they are available widely throughout the UK.For more information, pleasecontact us.
Source: Society for Endocrinology - Category: Endocrinology Source Type: news

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Nephrogenic diabetes insipidus (DI) secondary to a urinary tract obstruction is a rare condition. Herein, we report a case of partial nephrogenic DI due to obstructive uropathy in a patient with Castleman ’s di...
Source: BMC Nephrology - Category: Urology & Nephrology Authors: Tags: Case report Source Type: research
AbstractInsertion of an external ventricular drain (EVD) is one of the most common and most important lifesaving procedures encountered in the neurologic intensive care unit, but often done by the junior members of the team. A good number of complications may follow the insertion of EVD. In the available literature, only one case was reported with the placement of EVD in suprasellar cistern. There is no report of insertion or replacement of an EVD in the sella. Diabetes insipidus (DI) is also an unheard of complication of EVD. Here, we report a case where a patient with subarachnoid haemorrhage (SAH) with acute hydrocephal...
Source: Acta Neurochirurgica - Category: Neurosurgery Source Type: research
ConclusionThe pre-operative examination finding of no perception of light and the diagnosis of a giant pituitary adenoma measured in any dimension but especially antero-posteriorally are specific prognostic variables that demonstrate significance in predicting outcome in patients with giant pituitary adenomas being considered for the endoscopic endonasal transphenoidal approach.
Source: Interdisciplinary Neurosurgery - Category: Neurosurgery Source Type: research
PMID: 31061075 [PubMed - in process]
Source: cmaj - Category: General Medicine Authors: Tags: CMAJ Source Type: research
Conclusions: The signal intensity ratio of the posterior lobe, pituitary volume, and the morphology of pituitary stalk on T1WI-3D-MP RAGE image contribute to the diagnosis of CDI. PMID: 31049061 [PubMed]
Source: International Journal of Endocrinology - Category: Endocrinology Tags: Int J Endocrinol Source Type: research
Abstract Diabetes insipidus (DI), be it from central or nephrogenic origin, must be differentiated from secondary forms of hypotonic polyuria such as primary polydipsia. Differentiation is crucial since wrong treatment can have deleterious consequences. Since decades, the gold standard for differentiation has been the water deprivation test, which has limitations leading to an overall unsatisfying diagnostic accuracy. Furthermore, it is cumbersome for patients with a long test duration. Clinical signs and symptoms and MRI characteristics overlap between patients with DI and primary polydipsia. The direct test incl...
Source: European Journal of Endocrinology - Category: Endocrinology Authors: Tags: Eur J Endocrinol Source Type: research
AbstractRathke ’s cleft cysts (RCCs) are benign growths of the embryological Rathke’s pouch. Surgical decompression provides effective symptomatic relief in most cases; however, the effect of gross total resection (GTR) of the cyst wall on recurrence, as well as pituitary function, is unclear. The aim of this meta-analysis was to pool the current literature and ascertain the recurrence control afforded by GTR of the cyst wall compared with subtotal resection (STR). Searches of seven electronic databases from inception to January 2019 were conducted following PRISMA guidelines, resulting in 476 articles t o be s...
Source: Neurosurgical Review - Category: Neurosurgery Source Type: research
Sabrine Elkhodr Fluids and electrolytes: Polyuria, polydipsia, and diabetes insipidus In this video Joel Topf looks at how you can easily differentiate between different types of diabetes insipidus.
Source: Life in the Fast Lane - Category: Emergency Medicine Authors: Tags: Medmastery Podcast Central Diabetes Insipidus Fluids and Electrolytes Joel Topf polydipsia Polyuria Source Type: blogs
Shanshan Zhang1, Dongli Yuan2 and Ge Tan1* 1Department of Neurology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China 2The Institute of Medical Information, Chongqing Medical University, Chongqing, China Primary systemic vasculitis can affect every structure in both the central and peripheral nervous system, causing varied neurological manifestations of neurological dysfunction. Early recognition of the underlying causes of the neurological symptoms can facilitate timely treatment and improve the prognosis. This review highlights the clinical manifestations of primary systemic vasc...
Source: Frontiers in Neurology - Category: Neurology Source Type: research
In this study, the StCas9 derived from Streptococcus thermophilus together with the Drosha-mediated sgRNA-shRNA structure were combined to boost the G to A base editing on the IGF2 SNP site, which we called “SNP editing.” The codon-humanized StCas9 as we previously reported was firstly compared with the prevalently used SpCas9 derived from Streptococcus pyogenes using our idiomatic surrogate report assay, and the StCas9 demonstrated a comparable targeting activity. On the other hand, by combining shRNA with sgRNA, simultaneous gene silencing and genome targeting can be achieved. Thus, the novel IGF2.sgRNA-LIG4....
Source: Frontiers in Genetics - Category: Genetics & Stem Cells Source Type: research
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