New Society for Endocrinology Clinical Guidance published
The Society for Endocrinology’s Clinical Committee has produced two new Clinical Guidance documents: a clinical guidance for the inpatient management of cranial diabetes insipidus, and an emergency guidance for the acute management of the endocrine complications of checkpoint inhibitor therapy. These documents are for health professionals and aim to provide guidance to adequately assess and manage the patient. TheEndocrine Emergency Guidance for the acute management of the endocrine complications of checkpoint inhibitor therapy is the first specialty-specific guidance with endocrinology, oncology and acute medicine input.TheEndocrine Guidance for inpatient management of cranial diabetes insipidus (CDI) offers treatment pathways for patients with known CDI admitted to hospital. Following these guidelines is essential for the safe management of patients with CDI.We would appreciate your help to publicise these documents to ensure that they are available widely throughout the UK.For more information, pleasecontact us.
This study is to investigate the predictive value of posterior pituitary bright spot (PPBS) on magnetic resonance imaging (MRI) for postoperative diabetes insipidus (DI) in patients with pituitary adenoma. MATERIAL AND METHODS This was a retrospective study. In total, 65 patients with pituitary adenoma who underwent transsphenoidal surgery were enrolled. Before surgery, all patients had MRI examinations. The length of pituitary stalk and position of PPBS in T1WI sagittal and coronal sections were analyzed. The volume and height of the tumor was calculated in enhanced T1WI. Urine volume was monitored to analyze the clinical...
Authors: Chertok Shacham E, Ishay A PMID: 30221876 [PubMed - in process]
ConclusionLong-term follow-up showed a high remission rate in female prolactinoma patients, especially in microadenoma patients, after surgery. Transsphenoidal surgery performed by experienced neurosurgeons may offer a valuable approach to treat female microprolactinoma patients of child-bearing age with modern indications for surgery.
Pediatric Blood&Cancer, EarlyView.
CONCLUSION: A chordoid glioma is a rare neoplasm that, in 2000, was incorporated into the World Health Organization (WHO) classification of central nervous system tumors. Due to its rarity, it is seldom considered in the differential diagnosis of suprasellar masses. Moreover, its unusual presentation and difficult location present a challenge for surgical and medical management. PMID: 30188563 [PubMed - in process]
We report the case of a female who presented with pneumothorax and central diabetes insipidus, diagnosed as ACIF on lung biopsy. PMID: 30182689 [PubMed - in process]
Authors: Neal CJ, Bell RS, Carmichael JJ, DuBose JJ, Grabo DJ, Oh JS, Remick KN, Bailey JA, Stockinger ZT Abstract A catastrophic brain injury is defined as any brain injury that is expected to result in permanent loss of all brain function above the brain stem level. These clinical recommendations will help stabilize the patient so that they may be safely evacuated from theater. In addition to cardiovascular and hemodynamic goals, special attention must be paid to their endocrine dysfunction and its treatment-specifically steroid, insulin and thyroxin (t4) replacement while evaluating for and treating diabetes ins...
Authors: Abaziou T, Mrozek S, Srairi M, Gaussiat F, Marhar F, Osinski D, Menut R, Larcher C, Atthar V, Brauge D, Sol JC, Fourcade O, Geeraerts T PMID: 30182650 [PubMed - in process]
Abstract The original version of this Article erroneously cropped part of the abstract. The abstract has now been corrected to read 'Wolfram syndrome 1 (WS1) is a rare autosomal recessive neurodegenerative disease characterized by diabetes insipidus, diabetes mellitus, optic atrophy, deafness, and other abnormalities. WS1 usually results in death before the age of 50 years. The pathogenesis of WS1 is ascribed to mutations of human WFS1 gene on chromosome 4p encoding a transmembrane protein called wolframin, which has physiological functions in membrane trafficking, secretion, processing, and/or regulation of ER ca...
AbstractDiabetes insipidus is known to be associated with neurodevelopmental disorders. In this case report, we present a child suffering from a central diabetes insipidus (DI) and an attention-deficit/hyperactivity disorder (ADHD). The DI was due to a mutation on the vasopressin gene, impairing its secretion. We discuss the effects of this impairment on the central nervous system and how it might be linked to ADHD symptoms.