Treating Sickle Cell Disease in Africa

Homœopathic Links 2018; 31: 120-126 DOI: 10.1055/s-0038-1660439Sickle cell disease (SCD) is a condition causing lots of complications and suffering. In the past decades, treatment modalities have been developed that increase life expectancy and the quality of life of SCD patients. In Africa, these are not available, resulting in SCD patients to die young after many hospitalisations for serious and often painful crises. A new homeopathy-based remedy for SCD has been used with good results since 2013. [...] Thieme Medical and Scientific Publishers Private Ltd. Article in Thieme eJournals: Table of contents  |  Abstract  |  Full text
Source: Homoeopathic Links - Category: Complementary Medicine Authors: Tags: Materia Medica and Cases Source Type: research

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Conclusions: Children with SCD were found to have average basic fine motor dexterity and speed, but impaired VMI, a more complex fine motor skill. This finding is significant given the functional importance of complex fine motor skills in early academic activities.
Source: Journal of Pediatric Hematology Oncology - Category: Hematology Tags: Original Articles Source Type: research
We evaluated psychometric properties (validity, reliability, and responsiveness) of a modified Faces Pain Scale-Revised (FPS-R) in 257 patients with sickle cell anemia (SCA) 7 to below 18 years old in a randomized, multinational clinical study. The modified FPS-R asks patients to report, by daily diary, their worst intraday SCA-related pain. Intraclass correlation coefficient assessed test-retest reliability between month 1 and month 2. Pearson correlations between monthly mean SCA-related pain intensity, activity interference score, analgesic use, and opioid use assessed convergent validity. Responsiveness was assessed wi...
Source: Journal of Pediatric Hematology Oncology - Category: Hematology Tags: Original Articles Source Type: research
Condition:   Sickle Cell Nephropathy Intervention:   Other: patient with sickle cell disease Sponsor:   Assiut University Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
che F Abstract The most frequent causes of hemolytic anemias are immune or infectious diseases, drug induced hemolysis, thrombotic microangiopathies, hereditary spherocytosis, glucose-6-phosphate dehydrogenase or pyruvate kinase deficiencies, thalassemia's and sickle cell disease. Sometimes no cause is found because a rarer etiology is involved. The goal of this review is to remember some unfrequent constitutional or acquired causes and to point out difficulties to avoid wrong interpretations of analysis results. PMID: 30226192 [PubMed - in process]
Source: Annales de Biologie Clinique - Category: Biochemistry Authors: Tags: Ann Biol Clin (Paris) Source Type: research
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Source: Journal of Maternal-Fetal and Neonatal Medicine - Category: Perinatology & Neonatology Authors: Source Type: research
PMID: 30237267 [PubMed - as supplied by publisher]
Source: Haematologica - Category: Hematology Authors: Tags: Haematologica Source Type: research
Funding Opportunity RFA-NS-18-043 from the NIH Guide for Grants and Contracts. The purpose of this Funding Opportunity Announcement (FOA) is to promote the discovery and validation of novel therapeutic targets to facilitate the development of pain therapeutics. Specifically, the focus of this FOA is on the basic science discovery of targets in the peripheral nervous system, central nervous system, immune system or other tissues in the body that can be used to develop treatments that have minimal side effects and little to no abuse/addiction liability. Research supported by this FOA must include rigorous validation studies...
Source: NIH Funding Opportunities (Notices, PA, RFA) - Category: Research Source Type: funding
Authors: Masilamani V, Devanesan S, AlQathani F, AlShebly M, Daban HH, Canatan D, Farhat K, Jabry M, AlSalhi MS Abstract Sickle cell anemia (SCA) is an inherited blood disorder with worldwide incidence of 15%; out of this, it is found in up to 20% in countries like Kingdom of Saudi Arabia and Bahrain. The standard conventional method of detection is complete blood count (CBC) followed by hemoglobin electrophoresis or high-performance liquid chromatography (HPLC) or both. In this context, spectral detection of variants of sickle cell anemia (SCA) is an innovative technique, which when made accurate and reliable coul...
Source: Disease Markers - Category: Laboratory Medicine Tags: Dis Markers Source Type: research
The purpose of this Funding Opportunity Announcement (FOA) is to promote the discovery and validation of novel therapeutic targets to facilitate the development of pain therapeutics. Specifically, the focus of this FOA is on the basic science discovery of targets in the peripheral nervous system, central nervous system, immune system or other tissues in the body that can be used to develop treatments that have minimal side effects and little to no abuse/addiction liability. Research supported by this FOA must include rigorous validation studies to demonstrate the robustness of the target as a pain treatment target. This wi...
Source: NIDDK Funding Opportunities - Category: Endocrinology Source Type: funding
It ’s 1970 and 10-month-old Maurice Elias lay in a hospital bed in the pediatric intensive care unit dangerously malnourished, at just 14 pounds, and with a severe infection in his mouth. The antibiotics that doctors at UCLA had been using to treat Maurice, who had been born without a functional immu ne system, were no longer working.The only way Maurice was going to survive was a bone marrow transplant.“If we couldn't find a way to give Maurice a working immune system, he was going to die. And the only way to do so was with a risky transplant that could be fatal, too,” said Dr. Richard Stiehm, the UCLA d...
Source: UCLA Newsroom: Health Sciences - Category: Universities & Medical Training Source Type: news
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