Treating Sickle Cell Disease in Africa

Homœopathic Links 2018; 31: 120-126 DOI: 10.1055/s-0038-1660439Sickle cell disease (SCD) is a condition causing lots of complications and suffering. In the past decades, treatment modalities have been developed that increase life expectancy and the quality of life of SCD patients. In Africa, these are not available, resulting in SCD patients to die young after many hospitalisations for serious and often painful crises. A new homeopathy-based remedy for SCD has been used with good results since 2013. [...] Thieme Medical and Scientific Publishers Private Ltd. Article in Thieme eJournals: Table of contents  |  Abstract  |  Full text
Source: Homoeopathic Links - Category: Complementary Medicine Authors: Tags: Materia Medica and Cases Source Type: research

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Hopkins Nursing—No. 1 for Online Education body,#bodyTable,#bodyCell{ height:100% !important; margin:0; padding:0; width:100% !important; } table{ border-collapse:collapse; } img,a img{ border:0; outline:none; text-decoration:none; } h1,h2,h3,h4,h5,h6{ margin:0; padding:0; } p{ margin:1em 0; padding:0; } a{ word-wrap:break-word; } .mcnPreviewText{ display:none !important; } .ReadMsgBody{ width:100%; } .ExternalClass{ width:100%; } .ExternalClass,.ExternalClass p,.ExternalClass span,.ExternalClass font,.ExternalClass td,.Externa...
Source: Johns Hopkins University and Health Systems Archive - Category: Nursing Source Type: news
This study involved a total of 200 children who were divided into five groups comprising of 40 children each. Group SP included children who received prophylactic penicillin, Group SV who received pneumococcal vaccination, Group SPV who received both prophylactic penicillin and pneumococcal vaccination, Group SW who did not receive any prophylactic therapy and Group CC who were controls. Stimulated saliva samples from volunteers were collected and cultured in Mitis Salivarius Bacitracin (MSB) agar for estimation ofStreptococcus mutans. Decayed, Missing, Filled (DMFT) index/decayed, exfoliated, and filled tooth (deft) index...
Source: European Archives of Paediatric Dentistry - Category: Dentistry Source Type: research
Source: Annals of Hematology - Category: Hematology Source Type: research
Conclusion: SCT is associated with an increased risk for CAD in African American males with CKD. The excess risk in males with SCT appears to follow the same pattern as risk in males with SCD. Larger studies are needed to confirm these findings.Am J Nephrol 2019;49:93 –102
Source: American Journal of Nephrology - Category: Neurology Source Type: research
ConclusionSickle cell disease can be diagnosed by newborn screening but, as in this case, may have a delayed presentation. The delay in diagnosis of homozygous sickle cell disease illustrates that other genetic disorders should be considered in patients who already have a diagnosis of one Mendelian disorder but show atypical features.
Source: Journal of Medical Case Reports - Category: General Medicine Source Type: research
ConclusionsThe data shows a tendency towards lower DEAQ concentration in this limited population of SCD patients and the exploratory population PK estimates suggest altered DEAQ disposition in SCD patients with acute UM. These findings, which if confirmed, may reflect pathophysiological changes associated with SCD, have implications for therapeutic response to amodiaquine in SCD patients. The limited number of recruited SCD patients and sparse sampling approach however, limits extrapolation of the data, and calls for further studies in a larger population.
Source: Current Therapeutic Research - Category: Drugs & Pharmacology Source Type: research
Authors: Asare EV, Wilson I, Benneh-Akwasi Kuma AA, Dei-Adomakoh Y, Sey F, Olayemi E Abstract In Africa, sickle cell disease (SCD) is a major public health problem with over 200,000 babies born per year. In Ghana, approximately 15,000 (2%) of Ghanaian newborns are diagnosed with SCD annually. A retrospective review of medical records of all SCD patients aged 13 years and above, who presented to the sickle cell clinic at Ghana Institute of Clinical Genetics (GICG), Korle-Bu, from 1st January 2013 to 31st December 2014, was carried out, using a data abstraction instrument to document their phenotypes, demographics, a...
Source: Advances in Hematology - Category: Hematology Tags: Adv Hematol Source Type: research
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Source: Pediatric Hematology and Oncology - Category: Pediatrics Authors: Source Type: research
Publication date: Available online 11 January 2019Source: Redox BiologyAuthor(s): Anson MacKinney, Emily Woska, Ivan Spasojevic, Ines Batinic-Haberle, Rahima ZennadiAbstractIn sickle cell disease (SCD), recurrent painful vasoocclusive crisis are likely caused by repeated episodes of hypoxia and reoxygenation. The sickle erythrocyte (SSRBC) adhesion plays an active role in vasoocclusion. However, the effect of prolonged reoxygenation after hypoxic stress on the molecular mechanisms in SSRBCs involved in onset of episodic vasoocclusion remain unclear. Exposure of human SSRBCs to hypoxia followed by 2 hours reoxygenation...
Source: Redox Biology - Category: Biology Source Type: research
UCLA researchers led by Dr. Donald Kohn have created a method for modifying blood stem cells to reverse the genetic mutation that causes a life-threatening autoimmune syndrome called IPEX. The gene therapy, which was tested in mice, is similar to the technique Kohn has used to cure patients with another immune disease, severe combined immune deficiency, or SCID, also known as bubble baby disease.The workis described in a study published in the journal Cell Stem Cell.IPEX is caused by a mutation that prevents a gene called FoxP3 from making a protein needed for blood stem cells to produce immune cells called regulatory T ce...
Source: UCLA Newsroom: Health Sciences - Category: Universities & Medical Training Source Type: news
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