Treating Sickle Cell Disease in Africa
Homœopathic Links 2018; 31: 120-126 DOI: 10.1055/s-0038-1660439Sickle cell disease (SCD) is a condition causing lots of complications and suffering. In the past decades, treatment modalities have been developed that increase life expectancy and the quality of life of SCD patients. In Africa, these are not available, resulting in SCD patients to die young after many hospitalisations for serious and often painful crises. A new homeopathy-based remedy for SCD has been used with good results since 2013. [...] Thieme Medical and Scientific Publishers Private Ltd. Article in Thieme eJournals: Table of contents | Abstract | Full text
CONCLUSION: This study reported high rates of HBV markers of infection among SCD patients. It is therefore advocated that donated blood must pass through rigorous screening processes before it is transfused. PMID: 30024816 [PubMed - as supplied by publisher]
Emergency providers are likely to encounter sickle cell disease –related emergencies. The pathophysiology of emergent complaints are usually related to either an acute anemia or a vasoocclusive crisis. Differentiating between the two is the first step in the workup. Anemic crises must then be differentiated by the source. Vasoocclusive crises must be appropria tely treated with aggressive pain management, gentle hydration, and other appropriate adjuncts. Early recognition and treatment are key in providing excellent emergency care to those with sickle cell disease.
Condition: Sickle Cell Disease Interventions: Other: Peer Mentoring [PM]; Other: Structured Education Based Transition Program STE Sponsors: Ifeyinwa (Ify) Osunkwo MD MPH; Patient-Centered Outcomes Research Institute Not yet recruiting
CONCLUSIONS/IMPLICATIONSThis study provides a baseline assessment for examining trends in 30-day unplanned pediatric readmissions, an important quality metric as the provisions of the Children's Health Insurance Program Reauthorization Act and the Affordable Care Act are changed and implemented in the future. Over 50,000 pediatric hospital stays in 2014 occurred within 30 days of a previous hospitalization, with an average cost of $13,800. This report is timely, as the health care system works to become more patient-centered and public and private payers grapple with how to pay for quality care for children. The report pro...
Publication date: Available online 20 July 2018Source: The Lancet HaematologyAuthor(s): Carolyne M Ndila, Sophie Uyoga, Alexander W Macharia, Gideon Nyutu, Norbert Peshu, John Ojal, Mohammed Shebe, Kennedy O Awuondo, Neema Mturi, Benjamin Tsofa, Nuno Sepúlveda, Taane G Clark, Gavin Band, Geraldine Clarke, Kate Rowlands, Christina Hubbart, Anna Jeffreys, Silvia Kariuki, Kevin Marsh, Margaret MackinnonSummaryBackgroundHuman genetic factors are important determinants of malaria risk. We investigated associations between multiple candidate polymorphisms—many related to the structure or function of red blood cells&...
Publication date: Available online 19 July 2018Source: Blood Cells, Molecules, and DiseasesAuthor(s): Rayra Pereira Santiago, Caroline Conceição Guarda, Camylla Vilas Boas Figueiredo, Luciana Magalhaes Fiuza, Milena Magalhães Aleluia, Corynne Stephanie Ahouefa Adanho, Magda Oliveira Seixas Carvalho, Thassila Nogueira Pitanga, Dalila Luciola Zanette, Isa Menezes Lyra, Valma Maria Lopes Nascimento, Gregory M. Vercellotti, John D. Belcher, Marilda Souza Goncalves
The Journal of Physical Chemistry BDOI: 10.1021/acs.jpcb.8b03708
For people with sickle cell disease, oral twice-daily L-glutamine reduces hospitalization and trims the number of sickle cell crises compared with placebo, whether or not they are also receiving hydroxyurea, according to details of the key test that resulted in U.S. approval of the treatment just over a year ago.Reuters Health Information
Significantly fewer pain crises, hospitalizations compared with those receiving placebo
THURSDAY, July 19, 2018 -- For patients with sickle cell-related pain, those receiving oral therapy with L-glutamine have a lower median number of pain crises, according to a study published in the July 19 issue of the New England Journal of...