Virus-Induced Interferon- γ Causes Insulin Resistance in Skeletal Muscle and Derails Glycemic Control in Obesity

It is unknown how viral infections contribute to the progression of type 2 diabetes. Šestan and colleagues demonstrate that virus-induced interferon-γ increases muscle insulin resistance, which drives hyperinsulinemia to keep euglycemia and to boost anti-viral CD8+ T cell responses. This mechanism in obese subjects with hepatic IR derails glycemic control.

Source: Immunity - June 26, 2018 Category: Allergy & Immunology Authors: Marko Šestan, Sonja Marinović, Inga Kavazović, Đurđica Cekinović, Stephan Wueest, Tamara Turk Wensveen, Ilija Brizić, Stipan Jonjić, Daniel Konrad, Felix M. Wensveen, Bojan Polić Tags: Article Source Type: research