BCL3 regulates RANKL-induced osteoclastogenesis by interacting with TRAF6 in bone marrow-derived macrophages

Tumor necrosis factor receptor-associated factor 6 (TRAF6) is an essential component of the signaling complex that mediates osteoclastogenesis. As an adaptor protein of E3 ligase function, TRAF6 regulates NF- κB signaling via TAK1 and I-κB kinase (IKK) activation. Here, we investigated novel mechanisms by which TRAF6 signaling is regulated under receptor activator of nuclear factor-κB ligand (RANKL)-induced osteoclastogenesis.

Source: Bone - June 19, 2018 Category: Orthopaedics Authors: Kun Wang, Shuai Li, Yong Gao, Xiaobo Feng, Wei Liu, Rongjin Luo, Yu Song, JiTu, Yingle Liu, Cao Yang Tags: Full Length Article Source Type: research