Dendritic Vaccine for Glioblastoma: Hope Hyped, Say Some Dendritic Vaccine for Glioblastoma: Hope Hyped, Say Some

Survival for patients with newly diagnosed glioblastoma may be given a boost if initial results of dendritic vaccines using patients'own cells hold up. But experts are skeptical.Medscape Medical News
Source: Medscape Medical News Headlines - Category: Consumer Health News Tags: Hematology-Oncology News Source Type: news

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Abstract Human respiratory syncytial virus (HRSV) is a non-segmented negative stranded RNA virus and is recognized as the most important viral agent of lower respiratory tract infection worldwide, responsible for up to 199,000 deaths each year. The only FDA-approved regime to prevent HRSV-mediated disease is pre-exposure administration of a humanized HRSV-specific monoclonal antibody, which although being effective, is not in widespread usage due to its cost. No HRSV vaccine exists and so there remains a strong need for alternative and complementary anti-HRSV therapies. The HRSV M2-1 protein is a transcription fac...
Source: Sub-Cellular Biochemistry - Category: Biochemistry Authors: Tags: Subcell Biochem Source Type: research
Contributors : Hiroyuki Oshiumi ; Masaaki OkamotoSeries Type : Non-coding RNA profiling by arrayOrganism : Homo sapiensSera were collected from 6 healthy subjects, and the expression profiles of microRNAs in serum extracellular vesicles were investigated by 3D-gene microarray.The expression profile was used to investigate the correlation between immune responses to vaccines and microRNA expression levels.
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Non-coding RNA profiling by array Homo sapiens Source Type: research
AbstractInformation about Human Enterovirus circulation in Uruguay is scarce. The aim of this study was to generate the first description about their circulation in the country through the study of sewage samples collected before and after the switch from Oral Poliovirus Vaccine to Inactivated Poliovirus Vaccine. Viruses were concentrated by an adsorption –elution to a negatively charged membrane, and real-time quantitative PCR and qualitative PCR methods were used to detect, quantify, and characterize enteroviruses. Positive samples were inoculated in RD cells and two passages were performed. Additionally, RD+ sampl...
Source: Food and Environmental Virology - Category: Virology Source Type: research
The treatment development over the last decades for patients with NSCLC stage III disease has been disappointing despite numerous attempts to improve outcome. Strategies including addition of maintenance therapy (e.g. docetaxel), addition of targeted therapy (e.g. cetuximab) and introduction of newer chemotherapy agents such as pemetrexed or tumor vaccines all failed to increase survival beyond that provided by the presiding concept of concurrent chemoradiotherapy. A platinum-based chemotherapy doublet combined with radiation doses to 60  Gy, or somewhat higher, is still considered standard therapy in most clinics.
Source: Lung Cancer - Category: Cancer & Oncology Authors: Source Type: research
AbstractPurpose of ReviewIn the last 25  years, child mortality has significantly dropped at a global level. Understanding particularities of child mortality at the national level is useful to tailor health policy to those conditions requiring more attention. In Mozambique, a variety of efforts have been made to better characterize the o verall child mortality and to describe the main contributors for death. In this review, we attempt to contextualize current knowledge on causes of pediatric deaths in Mozambique.Recent FindingsThe available data regarding the principal causes of death in Mozambican children point out ...
Source: Current Tropical Medicine Reports - Category: Tropical Medicine Source Type: research
Abstract At a time when immunology seeks to progress ever more rapidly from characterization of a microbial or tumour antigen to the immune correlates that may define protective T-cell immunity, there is a need for robust tools to enable accurate predictions of peptide-major histocompatibility complex (pMHC) and peptide-MHC-T-cell receptor binding. Improvements in the curation of data sets from high throughput pMHC analysis, such as the NIH Immune Epitope Database (IEDB), and the associated developments of predictive tools rooted in machine-learning approaches, are having significant impact. When such approaches a...
Source: Immunology - Category: Allergy & Immunology Authors: Tags: Immunology Source Type: research
Authors: Sasaki E, Momose H, Hiradate Y, Furuhata K, Mizukami T, Hamaguchi I Abstract Safety evaluation of a human vaccine is critical for vaccine development and for preventing an unexpected adverse reaction in humans. Nonetheless, to date, very few systems have been described for preclinical studies of human adverse reactions in vivo. Previously, we have identified biomarker genes expressed in the lungs for evaluation of influenza vaccine safety, and their usefulness in rodent models and for adjuvant-containing vaccines has already been reported. Here, our purpose was to develop a novel humanized mouse model reta...
Source: Oncotarget - Category: Cancer & Oncology Tags: Oncotarget Source Type: research
Authors: Shan L, Kang X, Liu F, Cai X, Han X, Shang Y Abstract Vitamin D receptors (VDRs) are associated with the occurrence and development of asthma. The aim of the present study was to analyze the secondary structure and B‑cell and T‑cell epitopes of VDR using online prediction software and aid in the future development of a highly efficient epitope‑based vaccine against asthma. Blood samples were collected from peripheral blood of asthmatic children. Reverse transcription quantitative‑polymerase chain reaction (RT‑qPCR) was performed to detect the expression of VDR in the peripheral blood. Mouse model...
Source: Molecular Medicine Reports - Category: Molecular Biology Tags: Mol Med Rep Source Type: research
Condition:   Pancreatic Tumor Intervention:   Biological: Personalized neoantigen vaccine Sponsor:   Changhai Hospital Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Authors: Cohen JI Abstract Epstein-Barr virus (EBV) is the primary cause of infectious mononucleosis and is associated with several malignancies, including nasopharyngeal carcinoma, gastric carcinoma, Hodgkin lymphoma, Burkitt lymphoma, and lymphomas in immunocompromised persons, as well as multiple sclerosis. A vaccine is currently unavailable. While monomeric EBV gp350 was shown in a phase 2 trial to reduce the incidence of infectious mononucleosis, but not the rate of EBV infection, newer formulations of gp350 including multimeric forms, viruslike particles, and nanoparticles may be more effective. A vaccine tha...
Source: Advances in Experimental Medicine and Biology - Category: Research Tags: Adv Exp Med Biol Source Type: research
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