Active Women in Their 70s Beat Genetic Propensity to Obesity Active Women in Their 70s Beat Genetic Propensity to Obesity
' Our findings point to the importance of promoting and maintaining healthy behaviors particularly in older adults to maximize quality of life,'say the researchers.Medscape Medical News
(Reuters Health) - Obese people with knee osteoarthritis, a painful joint disease, may find greater symptom relief when they lose larger amounts of weight than when they shed fewer pounds, a recent study suggests.
In this study, JMJD3 was identified unexpectedly as a gene-specific transcriptional partner of SIRT1 and epigenetically activated mitochondrial β-oxidation, but not gluconeogenic, genes during fasting. Mechanistically, JMJD3, together with SIRT1 and the nuclear receptor PPARα, formed a positive autoregulatory loop upon fasting-activated PKA signaling and epigenetically activated β-oxidation–promoting genes, including Fgf21, Cpt1a, and Mcad. Liver-specific downregulation of JMJD3 resulted in intrinsic defects in β-oxidation, which contributed to hepatosteatosis as well as glucose and insulin intol...
Weight loss may be the best treatment for obese people with knee osteoarthritis.
BOSTON (CBS) – Doctors often recommend that overweight patients with arthritis of the knee lose weight to improve their pain and function, but how much weight loss makes a difference? A new study out of Wake Forest University in North Carolina finds that even a modest amount can pay big dividends when it comes to relieving symptoms. Researchers looked at 240 overweight and obese older adults with pain related to knee arthritis and found that those who lost 10-percent or more of their body weight over 18 months cut their pain in half. Losing 20-percent of body weight led to an additional 25-percent reduction in p...
The study, from University College London and published in Pediatric Obesity, suggests that genes are ‘largely unimportant’ when it comes to emotionally over- or under-eating.
Conditions: Overweight and Obesity; Weight Loss Maintenance; Dietary Habits Intervention: Behavioral: Weight Loss Maintenance (Control vs. Reverse Diet) Sponsor: University of Colorado, Denver Recruiting
Conditions: Obesity; Overweight Intervention: Drug: Liraglutide Sponsor: Novo Nordisk A/S Not yet recruiting
Condition: Morbid Obesity Intervention: Sponsor: University Of Perugia Recruiting
A study of mice with diet-induced obesity suggests that increases in anxiety and depression behavior may be due to gut bacteria altering brain chemistry.
Nonalcoholic fatty liver disease (NAFLD) is a common ailment. It is usually found in association with diabetes or obesity. There are no approved drugs to treat this condition. The study of flavonoid consumption has increased over the decades due to their antioxidative properties, although the literature is scarce when it comes to their effects in liver tissue. The purpose of this study was to evaluate the role of leucoanthocyanidin in nonalcoholic hepatic steatosis. Thirty male albino rabbits were divided in 3 groups. Group 1 had a regular commercial diet. The second group had a regular diet and 10 mL of egg yolk and 1.5 g...