Scientists find existing asthma drug can reverse memory loss in mice
Temple University experts claimed their findings on the drug zileuton open up a potential new route to stop the aggressive progression of Alzheimer's disease.
CONCLUSIONS: The Expert Group foresee an important role for EGb 761® , used alone or as an add-on therapy, in the treatment of MCI and dementias, particularly when patients do not derive benefit from acetylcholinesterase inhibitors or NMDA antagonists. EGb 761® should be used in alignment with local clinical practice guidelines. PMID: 30648358 [PubMed - in process]
More people are having asthma attacks than five years ago, data suggests. Charity Asthma UK said. Kelly May, 31, from London, has had hundreds of 'terrifying' attacks since she was a baby.
Authors: Kowalski K, Mulak A Abstract Disturbances along the brain-gut-microbiota axis may significantly contribute to the pathogenesis of neurodegenerative disorders. Alzheimer's disease (AD) is the most frequent cause of dementia characterized by a progressive decline in cognitive function associated with the formation of amyloid beta (Aβ) plaques and neurofibrillary tangles. Alterations in the gut microbiota composition induce increased permeability of the gut barrier and immune activation leading to systemic inflammation, which in turn may impair the blood-brain barrier and promote neuroinflammation, neura...
(MedPage Today) -- Frail older adults with Alzheimer's pathology showed more symptoms
Every three seconds in the UK, someone has an asthma attack which could be life-threatening, a charity says.
ConclusionThis study shows a link between work-related stress and incident asthma which seems to be confined to women. This study adds evidence about the association of work-related stress and asthma in young adults and can contribute to prevention for that particular age group.
Qiyang Shou, Lu Jin, Jiali Lang, Qiyuan Shan, Zhunan Ni, Changpei Cheng, Qinglin Li, Huiying Fu, Gang Cao
Long Pang, Junjie Wang, Lingling Zhao, Chunyu Wang, Hui Zhan
Much of the signaling that passes between cells travels via varieties of extracellular vesicle, tiny membrane-bound packages that contain a wide variety of presently poorly cataloged molecules. The varieties of vesicle are also poorly catalogued, and are at present given a loose taxonomy based on size. No doubt there are many subtypes within any given size category, depending on circumstance and mechanism, with the contents varying characteristically by subtype. Nothing is simple in cellular biology. Vesicles are currently a subject of growing interest in many fields of medical research. In regenerative medicine, fo...
Many of today’s most popular drugs can make you forgetful. They inhibit your brain’s chemical messengers. And this blocks your concentration, memory and ability to focus. More specifically, these drugs block the activity of a neurotransmitter in your brain called acetylcholine. Acetylcholine is directly involved in learning and memory. And blocking it is a risky business… I’ve seen confusion, memory loss, and declining mental skills in patients who take these drugs. New research confirms what I see in my own practice. One recent study found that people taking these kinds of drugs had shrunken ar...