Three Cases of Scalp Sarcoidosis with Alopecia.

Three Cases of Scalp Sarcoidosis with Alopecia. Actas Dermosifiliogr. 2018 May 29;: Authors: Ishikawa M, Ohtsuka M, Yamamoto T PMID: 29857946 [PubMed - as supplied by publisher]
Source: Actas Dermo-Sifiliograficas - Category: Dermatology Authors: Tags: Actas Dermosifiliogr Source Type: research

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We report a case of the concurrence of VKHD and sarcoidosis, which may share a common pathophysiology. Accumulation of further similar cases is necessary to elucidate the precise mechanism underlying the concurrence of these two diseases.Case Rep Ophthalmol 2019;10:32 –40
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Authors: Prohaska J, Demaree E, Powers J, Cook C Abstract Sarcoidosis is a granulomatous condition that has a highly variable presentation. One rare presentation of sarcoidosis is cutaneous scalp sarcoidosis. Usually scalp sarcoid presents as a scarring alopecia, but it can be nonscarring. The presence of sarcoidal lesions on the scalp is associated with systemic disease, as are other cutaneous manifestations of sarcoidosis. The authors present the case of a 64-year-old woman with a history of sarcoidosis who presented with alopecia and hypopigmented patches on her scalp. She also had papular sarcoid lesions on her...
Source: Journal of the American Osteopathic Association - Category: Complementary Medicine Tags: J Am Osteopath Assoc Source Type: research
Publication date: Available online 3 November 2018Source: Actas Dermo-Sifiliográficas (English Edition)Author(s): M. Ishikawa, M. Ohtsuka, T. Yamamoto
Source: Actas Dermo-Sifiliograficas - Category: Dermatology Source Type: research
yer N Abstract The development of immune checkpoint inhibitors (monoclonal antibodies targeting PD-1/PD-L1 or CTLA-4) represents a significant advance in the treatment of multiple cancers. Given their particular mechanism of action, which involves triggering CD4+/CD8+ T-cell activation and proliferation, they are associated with a specific safety profile. Their adverse events are primarily immune-related, and can affect practically all organs. In this context, dermatological toxicity is the most common, though it mostly remains mild to moderate and does not require discontinuation of treatment. More than a th...
Source: Annales de Dermatologie et de Cenereologie - Category: Dermatology Authors: Tags: Ann Dermatol Venereol Source Type: research
Abstract Sarcoidosis is a multisystem granulomatous disease most frequently affecting the lungs, lymph nodes, and eyes. Skin involvement occurs in approximately 25% to 35% of cases, with the scalp uncommonly affected. Abnormal calcium metabolism is associated with sarcoidosis and other granulomatous disorders and most commonly presents as hypercalciuria (40%-60%) and, less frequently, hypercalcemia (10%-20%). Symptomatic hypercalcemia is unusual, presenting in 14 mg/dL, 3.5 mmol/L), scarring alopecia, and acute-on-chronic kidney failure. PMID: 29706828 [PubMed]
Source: Baylor University Medical Center Proceedings - Category: Universities & Medical Training Authors: Tags: Proc (Bayl Univ Med Cent) Source Type: research
Abstract Understanding the effects of age on the epidemiology of diseases primarily affecting the skin is important to the practice of dermatology, both for proper allocation of resources and for optimal patient‐centered care. To fully appreciate the effect that age may have on the population‐based calculations of incidence of diseases primarily affecting the skin in Olmsted County, Minnesota, and worldwide, we performed a review of all relevant Rochester Epidemiology Project–published data and compared them to similar reports in the worldwide English literature. Using the Rochester Epidemiology Project, populati...
Source: International Journal of Dermatology - Category: Dermatology Authors: Tags: Review Source Type: research
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AbstractThe development of immune checkpoint inhibitors [monoclonal antibodies targeting cytotoxic T lymphocyte-associated antigen-4 (CTLA-4), programmed cell death protein 1 (PD-1) or programmed death ligand 1 (PD-L1)] represents a major breakthrough in cancer therapy. Although they present a favorable risk/benefit ratio, immune checkpoint blockade therapies have a very specific safety profile. Due to their unique mechanism of action, they entail a new spectrum of adverse events that are mostly immune related [immune-related adverse events (irAEs)], notably mediated by the triggering of cytotoxic CD4+/CD8+  T cell ac...
Source: American Journal of Clinical Dermatology - Category: Dermatology Source Type: research
Our lab previously published a genome-wide association study (GWAS) and meta-analysis to search for common alleles that contribute to risk of Alopecia Areata (AA), and identified genomic regions harboring potential susceptibility genes. One candidate susceptibility gene expressed in the hair follicle (HF) in AA is peroxiredoxin 5 (PRDX5) (p= 8.7*10-14), which is also a susceptibility gene in Crohn ’s disease, sarcoidosis, and psoriasis. PRDX5 is a member of the peroxiredoxin family of antioxidant enzymes crucial for regulating oxidative stress, which causes disruption in redox potentials that extend to the endoplasmi...
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Innate Immunity, Microbiology, Inflammation Source Type: research
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