Association of tumor-infiltrating T-cell density with molecular subtype, racial ancestry and clinical outcomes in prostate cancer

Association of tumor-infiltrating T-cell density with molecular subtype, racial ancestry and clinical outcomes in prostate cancerAssociation of tumor-infiltrating T-cell density with molecular subtype, racial ancestry and clinical outcomes in prostate cancer, Published online: 30 May 2018; doi:10.1038/s41379-018-0083-xAssociation of tumor-infiltrating T-cell density with molecular subtype, racial ancestry and clinical outcomes in prostate cancer
Source: Modern Pathology - Category: Pathology Authors: Source Type: research

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Two prostate cancer risk calculators that estimate the probability of reclassification with or without biopsy were validated in five large cohorts, researchers say - but using the calculators in the clinic can be complicated.Reuters Health Information
Source: Medscape Pathology Headlines - Category: Pathology Tags: Hematology-Oncology News Source Type: news
Publication date: Available online 12 September 2019Source: SteroidsAuthor(s): Debbie O'Reilly, Patricia Johnson, Paul.J BuchananAbstractAndrogen deprivation therapy (ADT) is the main treatment to prolong survival in advance stage prostate cancer (PCa) but associated resistance leads to the development of terminal castrate resistant PCa (CRPC). Current research demonstrates a critical role of prostate cancer stem cells (PCSC) in the development of treatment resistance and subsequent disease progression. Despite uncertainty surrounding the origin of these cells, studies clearly show they are associated with poorer outcomes ...
Source: Steroids - Category: Drugs & Pharmacology Source Type: research
Every year, tens thousands of men in the United States are diagnosed with low-risk prostate cancer. Most are told that they don ’t need treatment other than “active surveillance” to monitor their slow-growing tumors. Now, UCLA physicians have shown that the best way to proceed with this is by starting out with an MRI-guided prostate biopsy.In the past, doctors relied on ultrasound to guide a biopsy needle into the prostate. However, ultrasound doesn ’t allow the visualization of prostate tumors, so a biopsy may have missed a tumor. Over the past decade, it’s become possible to instead perform ...
Source: UCLA Newsroom: Health Sciences - Category: Universities & Medical Training Source Type: news
Ulrika Rosenström Simultaneous targeting of the prostate-specific membrane antigen (PSMA) and gastrin-releasing peptide receptor (GRPR) could improve the diagnostic accuracy in prostate cancer (PCa). The aim of this study was to develop a PSMA/GRPR-targeting bispecific heterodimer for SPECT and positron emission tomography (PET) diagnostic imaging of PCa. The heterodimer NOTA-DUPA-RM26 was produced by manual solid-phase peptide synthesis. NOTA-DUPA-RM26 was labeled with 111In and 68Ga, with yields >98%, and demonstrated a high stability and binding specificity to PSMA and GRPR. IC50 values for natIn-NOTA-DU...
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Article Source Type: research
Alejandro S. Godoy Tissue homeostasis is the result of a complex intercellular network controlling the behavior of every cell for the survival of the whole organism. In mammalian tissues, cells do communicate via diverse long- and short-range communication mechanisms. While long-range communication involves hormones through blood circulation and neural transmission, short-range communication mechanisms include either paracrine diffusible factors or direct interactions (e.g., gap junctions, intercellular bridges and tunneling nanotubes) or a mixture of both (e.g., exosomes). Tumor growth represents an alteration of tis...
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Review Source Type: research
ConclusionOur results confirm the validity of the ERSPC RC in a South African cohort. Application of this calculator to the wider South African population would allow better selection of patients for prostate biopsy and spare a significant number its adverse consequences.
Source: World Journal of Urology - Category: Urology & Nephrology Source Type: research
AbstractPurposeThe aim of this study was to investigate whether structured reports (SRs) of prostate MRI results are more suitable than non-structured reports (NSRs) for promoting the more accurate assessment of the location of a single prostate cancer lesion by novices in MRI-targeted biopsy.Methods50 NSRs and 50 SRs describing a single prostatic lesion were presented to 5 novices in MRI-targeted biopsy. The participants were asked to plot the tumor location in a two-dimensional prostate diagram and to answer a questionnaire on the quality of the reports. The accuracy of the plotted tumor position was evaluated with a val...
Source: World Journal of Urology - Category: Urology & Nephrology Source Type: research
Conditions:   Prostate Cancer;   Metastatic Castration-Resistant Prostate Cancer (mCRPC) Interventions:   Drug: AZD4635;   Drug: Oleclumab;   Drug: Durvalumab Sponsor:   AstraZeneca Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
A UK team has developed a novel test for prostate cancer using circulating tumor cells that, in combination with MRI, PSA, and a 12-gene panel, improved prostate cancer diagnosis noninvasively.Medscape Medical News
Source: Medscape Hematology-Oncology Headlines - Category: Cancer & Oncology Tags: Hematology-Oncology News Source Type: news
Publication date: Available online 13 September 2019Source: European UrologyAuthor(s): Antonio Alcaraz
Source: European Urology - Category: Urology & Nephrology Source Type: research
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