The Tumor Necrosis Factor Superfamily Member RANKL Suppresses Effector Cytokine Production in Group 3 Innate Lymphoid Cells

Although signals that activate group 3  ILCs (ILC3s) have been described, the factors that negatively regulate these cells are less well understood. Bando et al. demonstrate that the TNF superfamily member RANKL suppresses the abundance and effector functions of intestinal CCR6+ ILC3s and that RANKL-mediated suppression occurs through ILC3-ILC3 interactions.

Source: Immunity - May 29, 2018 Category: Allergy & Immunology Authors: Jennifer K. Bando, Susan Gilfillan, Christina Song, Keely G. McDonald, Stanley C.-C. Huang, Rodney D. Newberry, Yasuhiro Kobayashi, David S.J. Allan, James R. Carlyle, Marina Cella, Marco Colonna Tags: Article Source Type: research