Ustekinumab: Novel Help in Vasculitis?

(MedPage Today) -- Steroid-sparing effects demonstrated in small pilot study
Source: MedPage Today Primary Care - Category: Primary Care Source Type: news

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CONCLUSIONS: Our study for the first time indicated that disturbed ribosome-related disease modules might contribute to the development of KD. These modules could be considered as novel contributors to the progression of KD, and potential diagnostic biomarkers for predicting the clinical outcome. PMID: 30338808 [PubMed - in process]
Source: European Review for Medical and Pharmacological Sciences - Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research
Roche announced today that the U.S. Food and Drug Administration (FDA) has approved an update to the MabThera/Rituxan ® (rituximab) label to include information on follow up treatment of adult patients with Granulomatosis with Polyangiitis (GPA) and Microscopic Polyangiitis (MPA) who have achieved disease control with induction treatment.
Source: Roche Investor Update - Category: Pharmaceuticals Source Type: news
Histone deacetylase inhibitors (HDACis) prevent chromatin condensation and affect gene transcription. HDACis increase the activity of the P53 tumor suppressor but block T- and B-cell transcription factors, resulting in cell cycle arrest and apoptosis of leukocytes responding to antigen. HDACis work synergistically with alkylating agents because an open chromatin structure allows alkylating agents better access to DNA. Dooley and colleagues tested EDO-S101, a dual HDACi and alkylating agent, in 2 models of myeloperoxidase (MPO) vasculitis.
Source: Kidney International - Category: Urology & Nephrology Tags: In This Issue Source Type: research
Anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis causes end-stage renal failure in up to a third of cases even with treatment. The disease recurs occasionally after kidney transplantation, but...
Source: BMC Nephrology - Category: Urology & Nephrology Authors: Tags: Case report Source Type: research
SUMMARY The authors report a case of a 69-year-old man with idiopathic leukocytoclastic cutaneous vasculitis. For three years, the lesions recurred with progressive worsening and were associated with systemic manifestations of low-grade fever, weight loss and raised inflammatory markers. The patient latter presented a 6th cranial nerve involvement, raising the concern of a possible systemic vasculitis, which was latter evidenced by the development of deep vein thrombosis and angina pectoris. The treatment of the patient witch based on the decreasing of inflammatory activity, by using effective immunosuppressive therapy, wi...
Source: Revista da Associacao Medica Brasileira - Category: General Medicine Source Type: research
ConclusionPanniculitis of the breast is a rare condition that needs to be included in the differential diagnosis of subcutaneous breast masses. In all cases, but specifically in females with history of breast cancer, panniculitis still should be thought of as a possibility, and imaging as well as other diagnostic techniques can aid in making the correct diagnosis.
Source: Annals of Medicine and Surgery - Category: General Medicine Source Type: research
Severe infections occurred in 25% of patients with anti-neutrophil cytoplasm antibody (ANCA) associated vasculitis (AAV) who were treated with rituximab, according to results of an observational study conducted in the United Kingdom (U.K.) and Austria. Trimethoprim-sulfamethoxazole (TMP/SMX) prophylaxis, however, reduced the risk of severe infections, the investigators reported in Annals of the Rheumatic Diseases.1 Andreas... [Read More]
Source: The Rheumatologist - Category: Rheumatology Authors: Tags: Conditions Drug Updates Vasculitis antibody-associated vasculitis Infection rituximab Source Type: research
Giant cell arteritis is a granulomatous immune-mediated vasculitis of medium and large vessels. It most commonly affects white females over the age of 50 and is the most common primary vasculitis in the United States. Treatment of this disease has classically been with high-dose corticosteroids, but this therapy has been associated with severe morbidity and mortality. Tocilizumab, a humanized monoclonal antibody targeting the interleukin-6 receptor, has been used with great efficacy and safety in rheumatoid arthritis and systemic-onset juvenile idiopathic arthritis. As interleukin-6 has been shown to be a key cytokine in g...
Source: Cardiology in Review - Category: Cardiology Tags: Review Articles Source Type: research
Abstract Objective We aim to explore the differences of skin signs between juvenile- and adult-onset systemic lupus erythematosus and to identify their associations to the development of systemic involvement. Methods A retrospective chart review of 377 systemic lupus erythematosus patients was performed. Results In total, 171 patients with juvenile systemic lupus erythematosus and 206 with adult systemic lupus erythematosus were studied. All patients were of Southeast Asian descent. The mean duration of follow up was 8.18 ± 6.19 and 9.36 ± 7.68 years for juvenile systemic ...
Source: Lupus - Category: Rheumatology Authors: Tags: Lupus Source Type: research
ConclusionIn this analysis of French death certificates mentioning GCA, we observed a stable standardized mortality rate between 2005 and 2014. The most frequent associated diseases were cardiovascular diseases and infections.
Source: Autoimmunity Reviews - Category: Allergy & Immunology Source Type: research
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