Ustekinumab: Novel Help in Vasculitis?

(MedPage Today) -- Steroid-sparing effects demonstrated in small pilot study
Source: MedPage Today Primary Care - Category: Primary Care Source Type: news

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Publication date: Available online 16 August 2018Source: Best Practice &Research Clinical RheumatologyAuthor(s): Elena Csernok, Xavier BossuytAbstractThe diagnosis of systemic vasculitis is challenging. Laboratory testing may provide useful information. Routine laboratory tests include erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), blood count, serum creatinine, urinalysis, specific autoantibodies, complement, immunoglobulin, cryoglobulin, and Hepatitis B and C serology. Although ESR and CRP are often helpful for the diagnosis of vasculitis, they are nonspecific and do not help in distinguishing betwee...
Source: Best Practice and Research Clinical Rheumatology - Category: Rheumatology Source Type: research
This study sought to evaluate the occurrence and nature of vasculitis associated with cancer treatment using immune checkpoint inhibition (anti-PD-1, anti-PDL-1, and anti-CTLA4). A systematic review of the medical literature was conducted by searching all available clinical data up to February 2018 in several databases and search engines including Cochrane Library, Embase, Google Scholar, Medline, Scopus, Web of Science, andClinicaltrials.gov. Searches included the following FDA-approved anti-PD1 (nivolumab and pembrolizumab), anti-PDL1 (atezolizumab, avelumab, and durvalumab), and anti-CTLA4 (ipilimumab). The vasculitis c...
Source: Clinical Rheumatology - Category: Rheumatology Source Type: research
Conclusion IgAVN in elderly patients is characterized by severe renal involvement. Elderly patients are at higher risk than adults for treatment-related adverse events. PMID: 30101942 [PubMed - as supplied by publisher]
Source: Internal Medicine - Category: Internal Medicine Tags: Intern Med Source Type: research
This study provides class IV evidence that elevated sVEGF levels accurately identifies patients with POEMS syndrome.
Source: Neurology Neuroimmunology and Neuroinflammation - Category: Neurology Authors: Tags: Diagnostic test assessment, Hematologic, Peripheral neuropathy Article Source Type: research
Publication date: Available online 14 August 2018Source: Autoimmunity ReviewsAuthor(s): Michele Iudici, Pierre Quartier, Christian Pagnoux, Etienne Merlin, Christian Agard, Achille Aouba, Pascal Roblot, Pascal Cohen, Benjamin Terrier, Luc Mouthon, Loïc Guillevin, Xavier Puéchal, the French Vasculitis Study GroupAbstractObjectiveTo investigate differences between childhood (cPAN)- and adult-onset polyarteritis nodosa (aPAN) patients.MethodscPAN patients' clinical findings at onset and outcomes were compared to those of aPAN patients from the French Vasculitis Study Group registry matched for year of enrollment a...
Source: Autoimmunity Reviews - Category: Allergy & Immunology Source Type: research
Seza Ozen, Ezgi Deniz Batu
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
Endocrine Practice, Ahead of Print.
Source: Endocrine Practice - Category: Endocrinology Authors: Source Type: research
B cell therapy in ANCA-associated vasculitis: current and emerging treatment options, Published online: 14 August 2018; doi:10.1038/s41584-018-0065-xB cell depletion has become standard-of-care for the treatment of ANCA-associated vasculitis, but can more be done to target B cells? In this Review, the authors look beyond rituximab to alternative B cell-targeting therapies and novel therapeutic combinations.
Source: Nature Reviews Rheumatology - Category: Rheumatology Authors: Source Type: research
CONCLUSION: AAG in SSc is rare, with disease manifestation and course similar to that of AAV. This case series demonstrates that disease remission can be achieved with standard induction therapy. Vasculitis relapse can occur, and similar to idiopathic AAV, maintenance immunosuppression should be initiated to maintain remission.
. PMID: 30106367 [PubMed - as supplied by publisher]
Source: Clinical Nephrology - Category: Urology & Nephrology Authors: Tags: Clin Nephrol Source Type: research
Authors: Chaudhry R, Bilal A, Austin A, Mehta S, Salman L, Foulke L, Feustel P, Zuckerman R, Asif A Abstract BACKGROUND AND OBJECTIVES: Anti-neutrophil cytoplasmic autoantibodies (ANCA) associated vasculitis is a small vessel vasculitis with insufficient epidemiologic estimates in the United States. We aimed to determine demographic and clinical features of ANCA associated vasculitis patients presenting to a large tertiary care referral center in Upstate New York. Design, setting, participants, and measurements: A retrospective analysis of cases with pauci-immune GN on renal biopsy and clinical diagnosis of ANCA va...
Source: Jornal Brasileiro de Nefrologia - Category: Urology & Nephrology Tags: J Bras Nefrol Source Type: research
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