Limiting Chemo to High-Risk Rectal Cancer Called Feasible

(MedPage Today) -- Approach that includes MRI-based selection didn't boost local recurrence rates
Source: MedPage Today Gastroenterology - Category: Gastroenterology Source Type: news

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Publication date: Available online 17 August 2018Source: Journal of Visceral SurgeryAuthor(s): T. Sarcher, B. Dupont, A. Alves, B. MenahemSummaryMultidisciplinary management of infra-peritoneal rectal cancer has pushed back the frontiers of sphincter preservation, without impairment of carcinological outcome. However, functional intestinal sequelae, grouping together several symptoms known under the name of anterior resection syndrome (ARS), have emerged and become an increasingly frequent concern for both patients and physicians. The pathophysiology is complex: ARS is a combination in various degrees of stool frequency, i...
Source: Journal of Visceral Surgery - Category: Surgery Source Type: research
Publication date: September 2018Source: European Journal of Surgical Oncology, Volume 44, Issue 9Author(s): A.J. Breugom, E. Bastiaannet, P.G. Boelens, E. Van Eycken, L.H. Iversen, A. Martling, R. Johansson, T. Evans, S. Lawton, K.M. O'Brien, H. Ortiz, R. Janciauskiene, O.M. Dekkers, H.J.T. Rutten, G.J. Liefers, V.E.P.P. Lemmens, C.J.H. van de VeldeAbstractIntroductionThe aim of this EURECCA international comparison is to compare oncologic treatment strategies and relative survival of patients with stage I–III rectal cancer between European countries.Material and methodsPopulation-based national cohort data from the ...
Source: European Journal of Surgical Oncology (EJSO) - Category: Surgery Source Type: research
Authors: McGee SF, AlGhareeb W, Ahmad CH, Armstrong D, Babak S, Berry S, Biagi J, Booth C, Bossé D, Champion P, Colwell B, Finn N, Goel R, Gray S, Green J, Harb M, Hyde A, Jeyakumar A, Jonker D, Kanagaratnam S, Kavan P, MacMillan A, Muinuddin A, Patil N, Porter G, Powell E, Ramjeesingh R, Raza M, Rorke S, Seal M, Servidio-Italiano F, Siddiqui J, Simms J, Smithson L, Snow S, St-Hilaire E, Stuckless T, Tate A, Tehfe M, Thirlwell M, Tsvetkova E, Valdes M, Vickers M, Virik K, Welch S, Marginean C, Asmis T Abstract The annual Eastern Canadian Gastrointestinal Cancer Consensus Conference 2017 was held in St. John'...
Source: Current Oncology - Category: Cancer & Oncology Tags: Curr Oncol Source Type: research
Conclusion.The pCR rate (our primary endpoint), at only 10.9%, did not reach the specified level considered suitable for further testing. However, the analysis showed a good toxicity profile and compliance to concomitant administration of panitumumab and RTE in preoperative treatment of LARC. The pCR evaluation in all wild‐type RAS is ongoing.Implications for Practice.The aim of the RaP/STAR‐03 study was to evaluate the activity and safety of monoclonal antibody anti‐epidermal growth factor receptor (EGFR) panitumumab as a single agent without chemotherapy in low‐risk, locally advanced rectal cancer (LARC) preopera...
Source: The Oncologist - Category: Cancer & Oncology Authors: Tags: Gastrointestinal Cancer Source Type: research
AbstractSeveral studies have reported high rates of urogenital dysfunction after open and laparoscopic surgery for rectal cancer. Robotic surgery has several features that could facilitate identification and preservation of autonomic nerves. This manuscript aims to summarize the literature regarding urogenital function after robotic rectal cancer surgery and focus on technical aspects of nerve-sparing total mesorectal excision. Comprehensive searches were conducted through online databases. Selection criteria included: original articles assessing urinary and sexual function after robotic surgery of males and/or females wit...
Source: Updates in Surgery - Category: Surgery Source Type: research
Conditions:   Rectal Cancer;   Metastasis;   Radiotherapy Intervention:   Combination Product: IMRT + oral chemotherapy Sponsor:   Institut Cancerologie de l'Ouest Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
A score incorporating categories for disease-free survival can help clinicians make faster decisions about treatment for rectal cancer.Annals of Oncology
Source: Medscape Today Headlines - Category: Consumer Health News Tags: Hematology-Oncology Journal Article Source Type: news
Publication date: Available online 15 August 2018Source: European Journal of Surgical OncologyAuthor(s): Isacco Montroni, Giampaolo Ugolini, Nicole M. Saur, Antonino Spinelli, Siri Rostoft, Monica Millan, Albert Wolthuis, Ian R. Daniels, Roel Hompes, M. Marta Penna, Alois Fürst, Demetris Papamichael, Avni M. Desai, Stefano Cascinu, Jean-Pierre Gèrard, Arthur Sun Myint, Valery EPP. Lemmens, Mariana Berho, Mark Lawler, Nicola De Liguori CarinoAbstractWith an expanding elderly population and median rectal cancer detection age of 70 years, the prevalence of rectal cancer in elderly patients is increasing. Managemen...
Source: European Journal of Surgical Oncology (EJSO) - Category: Surgery Source Type: research
A prospective phase II study of pre-operative chemotherapy then short-course radiotherapy for high risk rectal cancer: COPERNICUS, Published online: 15 August 2018; doi:10.1038/s41416-018-0209-4A prospective phase II study of pre-operative chemotherapy then short-course radiotherapy for high risk rectal cancer: COPERNICUS
Source: British Journal of Cancer - Category: Cancer & Oncology Authors: Source Type: research
In conclusion, the proposed CAC-SPP which could extract high-resolution features with large receptive fields and capture multi-scale context yields improve the accuracy of segmentation performance for rectal tumors. PMID: 30109986 [PubMed - as supplied by publisher]
Source: Physics in Medicine and Biology - Category: Physics Authors: Tags: Phys Med Biol Source Type: research
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