Limiting Chemo to High-Risk Rectal Cancer Called Feasible

(MedPage Today) -- Approach that includes MRI-based selection didn't boost local recurrence rates
Source: MedPage Today Gastroenterology - Category: Gastroenterology Source Type: news

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Authors: Xu J, Li X, Lv X Abstract Efficacy of the combination of oxaliplatin, 5-fluorouracil and radiotherapy on rectal cancer in elderly patients was investigated. Seventy-three elderly patients with rectal cancer confirmed by histopathological examination were randomly divided into 3 groups: oxaliplatin group (25 cases): intravenous infusion of oxaliplatin; fluorouracil group (24 cases): intravenous infusion of fluorouracil; combination group (24 cases), intravenous infusion of oxaliplatin and fluorouracil. All patients were treated with radiotherapy, and efficacy and safety were evaluated after 2 courses of tre...
Source: Experimental and Therapeutic Medicine - Category: General Medicine Tags: Exp Ther Med Source Type: research
The radiation oncologist point of view on "Predictive value of 18F-FDG PET/CT on survival in locally advanced rectal cancer after neoadjuvant chemoradiation". Eur Rev Med Pharmacol Sci. 2019 Feb;23(3):903-905 Authors: Signor MA, Parisi G, Chiaulon G, Trovo M PMID: 30779052 [PubMed - in process]
Source: European Review for Medical and Pharmacological Sciences - Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research
AbstractPurposeLow anterior resection with coloanal anastomosis (CAA) for low rectal cancer is a technically difficult operation with limited data available on oncologic outcomes. We aim to investigate overall survival and operative oncologic outcomes in patients who underwent CAA compared to abdominoperineal resection (APR).MethodsThe National Cancer Database (2004 –2013) was used to identify patients with non-metastatic rectal adenocarcinoma who underwent CAA or APR. Patients were 1:1 matched on age, gender, Charlson score, tumor size, tumor grade, pathologic stage, and radiation treatment with propensity scores. T...
Source: International Journal of Colorectal Disease - Category: Gastroenterology Source Type: research
Tumor deposit (TD) is an independent poor prognostic factor in locally advanced rectal cancer (LARC) patients following neo ‐CRT, especially in patients with no more than one positive lymph node (LN). One TD probably should be considered as one positive LN when performing N staging. AbstractTumor deposit (TD) was associated with poor survival in colorectal cancer. However, its prognostic and staging value in locally advanced rectal cancer (LARC) patients following neoadjuvant chemoradiotherapy (neo ‐CRT) is controversial. Four hundred and ninety‐five LARC patients following neo‐CRT and surgery were retrospectively ...
Source: Cancer Medicine - Category: Cancer & Oncology Authors: Tags: ORIGINAL RESEARCH Source Type: research
The objective is to investigate preoperative body mass index (BMI) in patients receiving beyond total mesorectal excision (bTME) surgery. The primary end point is length of postoperative stay. Secondary end points are length of intensive care stay, postoperative morbidity and overall survival. BMI is the most commonly used anthropometric measurement of nutrition and studies have shown that overweight and obese patients can have improved surgical outcomes. Patients who underwent a bTME operation for locally advanced or recurrent rectal cancer were put into three BMI (kg/m2) groups of normal weight (18.5 –24.9), overwe...
Source: Updates in Surgery - Category: Surgery Source Type: research
AbstractTo determine the role of MRI as a predictor of circumferential resection margin (CRM) involvement. To study the impact of CRM status on MRI on recurrence and survival, in correlation with pathology. Analysis of a prospective database was performed over a period of 1  year. All patients with adenocarcinoma of rectum were included in the study. The MRI at presentation for all patients irrespective of stage (MRIT), pre-NACTRT MRI (MRI1) for patients with locally advanced tumours, and post-NACTRT MRI (MRI2) of these patients were analysed separately. The status of CRM on MRI was compared to that on histopathology ...
Source: Indian Journal of Surgical Oncology - Category: Cancer & Oncology Source Type: research
Conditions:   Rectal Cancer;   Lymph Node Metastases Intervention:   Sponsor:   Västerbotten County Council Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Conditions:   Rectal Cancer;   Organ Preservation Intervention:   Procedure: standard TME surgery Sponsors:   Yuan-hong Gao;   Sixth Affiliated Hospital, Sun Yat-sen University;   Beijing Cancer Hospital;   Second Affiliated Hospital, School of Medicine, Zhejiang University;   Fujian Medical University Union Hospital;   Fujian Cancer Hospital;   Tongji Hospital Active, not recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Conditions:   Rectal Cancer;   Lymph Node Metastases Intervention:   Sponsor:   Västerbotten County Council Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Conditions:   Rectal Cancer;   Organ Preservation Intervention:   Procedure: standard TME surgery Sponsors:   Yuan-hong Gao;   Sixth Affiliated Hospital, Sun Yat-sen University;   Beijing Cancer Hospital;   Second Affiliated Hospital, School of Medicine, Zhejiang University;   Fujian Medical University Union Hospital;   Fujian Cancer Hospital;   Tongji Hospital Active, not recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
More News: Cancer | Cancer & Oncology | Gastroenterology | Rectal Cancers