Limiting Chemo to High-Risk Rectal Cancer Called Feasible

(MedPage Today) -- Approach that includes MRI-based selection didn't boost local recurrence rates
Source: MedPage Today Gastroenterology - Category: Gastroenterology Source Type: news

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Conditions:   Rectal Cancer;   Rectal Neoplasms;   Rectal Cancer Stage II;   Rectal Cancer Stage III Interventions:   Radiation: Radiotherapy;   Drug: Chemotherapy;   Other: Deep regional hyperthermia Sponsor:   University Hospital Tuebingen Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Conclusion: An intraoperative frozen pathology examination was helpful for the additional resection, when unexpected distal spreading had occurred in rectal cancer. The evidence of a distal negative margin should not be underestimated.Case Rep Gastroenterol 2018;12:297 –302
Source: Case Reports in Gastroenterology - Category: Gastroenterology Source Type: research
Conclusion The interobserver and intermethod correlations for most of the histogram metrics of the DCE parameters are excellent in rectal cancer. Therefore, the single-section method may be a potential alternative to the whole-tumor volume method using pre-CRT MRI, despite the fact that the high agreement between the two methods cannot be extrapolated to post-CRT MRI.
Source: Diagnostic and Interventional Imaging - Category: Radiology Source Type: research
We examined the prognostic role of clinicopathological factors for ypN-positivity in patients with ypT0-2 rectal carcinoma treated within the CAO/ARO/AIO-94 and CAO/ARO/AIO-04 randomized phase 3 trials.
Source: Radiotherapy and Oncology - Category: Radiology Authors: Tags: Original article Source Type: research
The objective of this study was to demonstrate if pre-operative NLR has a role in predicting post-operative septic complications in patients undergoing rectal cancer surgery.MethodologyConsecutive patients undergoing scheduled resection for rectal cancer in a tertiary centre from July 2007 to Dec 2015 were included. Data was gathered from a prospectively held database of rectal cancer. Normally distributed data were compared with pairedt tests (mean  ± standard error in the mean (SEM)), and proportions were compared with Fisher’s exact test. Ap value of
Source: International Journal of Colorectal Disease - Category: Gastroenterology Source Type: research
AbstractPurposeThe prediction of an infiltration of the mesorectal fascia (MRF) and malignant lymph nodes is essential for treatment planning and prognosis of patients with rectal cancer. The aim of this study was to assess the additional diagnostic value of dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) for the detection of a malignant involvement of the MRF and of mesorectal lymph nodes in patients with locally advanced rectal cancer.MethodsIn this prospective study, 22 patients with locally advanced rectal cancer were examined with 1.5-T MRI between September 2012 and April 2015. Histopathological assess...
Source: International Journal of Colorectal Disease - Category: Gastroenterology Source Type: research
Conclusions: Our study suggested that multidisciplinary treatment with local excision plus CRT can be used as a treatment option in selected patients with clinical T1N0M0 rectal cancer.Oncology
Source: Oncology - Category: Cancer & Oncology Source Type: research
Abstract OBJECTIVE: The National Comprehensive Cancer Network (NCCN) guidelines recommend local excision and observation as standard treatment for selected patients with clinical T1N0M0 rectal cancer. In patients with pathological T1 (pT1) rectal cancer who received local excision, the local recurrence rate is at least 10%. We studied oncological outcomes in patients with pT1 rectal cancer who received chemoradiotherapy (CRT) after local excision. METHODS: Local excision was performed in 65 patients with clinical T1N0M0 rectal cancer (≤8 cm from the anal verge, tumor size
Source: Oncology - Category: Cancer & Oncology Authors: Tags: Oncology Source Type: research
The objective of this project was to investigate the independent and combined associations of ST and PA with the risk of incident CRC, specifically colon and rectal cancer. Participants in the Women’s Health Initiative Observational Study (n=74 870), 50–79 years of age self-reported ST and PA at baseline, years 3 and 6. Incident CRC was the primary outcome; colon and rectal cancers were the secondary outcomes, which were centrally adjudicated. Over a 13-year follow-up period, 1145 incident cases of CRC were documented. A positive age-adjusted association was found between higher ST (≥10 vs. 20 MET-h/w...
Source: European Journal of Cancer Prevention - Category: Cancer & Oncology Tags: Research Papers: Gastrointestinal Cancer Source Type: research
Conclusions: Weekend emergency colon cancer surgery was associated with higher mortality and severe complication rates. More research is needed to understand which factors explain and contribute to these differences. PMID: 29891525 [PubMed - in process]
Source: Journal of the National Comprehensive Cancer Network : JNCCN - Category: Cancer & Oncology Tags: J Natl Compr Canc Netw Source Type: research
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