LYME disease & co-infections: role of adaptive immune system

Future Microbiology, Ahead of Print.
Source: Future Microbiology - Category: Microbiology Authors: Source Type: research

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Laura Macleod, 31, tested positive for Lyme disease in 2016 but the standard treatment did nothing to alleviate her symptoms. Now, wants to travel to Germany for dangerous full body heating.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news
Source: International Journal of General Medicine - Category: General Medicine Tags: International Journal of General Medicine Source Type: research
Source: Neurological Sciences - Category: Neurology Source Type: research
Authors: Ranque-Garnier S, Eldin C, Sault C, Raoult D, Donnet A Abstract Lyme disease is caused by bacteria of the B. burgdorferi sensu lato complex, and can give polymorphic clinical manifestations that can affect several organs such as the skin, the central nervous system, or the joints. In recent years, patients' associations and physicians have been supporting the hypothesis that this infection would manifest as chronic generalized musculoskeletal pain symptoms, named "chronic Lyme disease". Fibromyalgia is a clinical presentation characterized by chronic generalized musculoskeletal pain with a m...
Source: Medecine et Maladies Infectieuses - Category: Infectious Diseases Tags: Med Mal Infect Source Type: research
Authors: Eldin C, Jaulhac B, Mediannikov O, Arzouni JP, Raoult D Abstract Bacteria of the Borrelia burgdorferi sensu lato complex, responsible for Lyme disease, are members of the spirochetes phylum. Diagnostic difficulties of Lyme disease are partly due to the characteristics of spirochetes as their culture is tedious or even impossible for some of them. We performed a literature review to assess the value of the various diagnostic tests of spirochetes infections of medical interest such as Lyme borreliosis, relapsing fever borreliae, syphilis, and leptospirosis. We were able to draw similarities between these fou...
Source: Medecine et Maladies Infectieuses - Category: Infectious Diseases Tags: Med Mal Infect Source Type: research
This meta-analysis suggests that when symptoms of the disease are confined to a localised skin infection, treatment failures are relatively infrequent, only 2% at 12 months. Effective antibiotics include penicillin V, doxycycline, azithromycin, cefuroxime, amoxicillin and ceftriaxone plus doxycycline.The research has significant limitations, but choice, dose and duration of antibiotics appear to have little impact on outcomes. This research does not suggest that guidelines need to be reviewed.
Source: Current Awareness Service for Health (CASH) - Category: Consumer Health News Source Type: news
Contributors : Jerome Bouquet ; Charles Y ChiuSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensMost Lyme disease patients treated with appropriate antibiotics recover rapidly and completely, but a minority of patients develop persistent symptoms correlating with disseminated disease, a greater severity of illness at presentation, and delayed antibiotic therapy. When lingering or recurrent symptoms are associated with a functional decline and persist for greater than 6 months, patients are considered to meet clinical criteria for post-treatment Lyme disease syndrome (PTLDS), although th...
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
This study aimed to investigate the presence and perform molecular characterization of Anaplasmataceae, Rickettsia spp., and Borrelia burgdorferi sensu lato (sl) in tick species collected in Corsica. Ticks from cattle (Bos taurus), sheep (Ovis aries), and rodents (Rattus rattus) were collected from May to September 2016. DNA was purified from ticks, submitted to quantitative real-time polymerase chain reaction (qPCR) and sequenced for phylogenetic analysis. In total, 660 ticks were collected from 111 animals during the study. The most abundant collected tick species from cattle was Rhipicephalus bursa (n = 49...
Source: Ticks and Tick borne Diseases - Category: Zoology Source Type: research
LYME disease is a bacterial infection which is spread to humans by infected ticks. Blood tests have been available for some time to confirm or rule out the condition. But now health experts are advising doctors a ‘bull’s eye’ rash alone can diagnose Lyme disease.
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
The UK's National Institute for Health and Care Excellence urges medics to just look for the rash - which is present in around two-thirds of cases - due to lab tests not always picking up on the infection.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news
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