Peritoneal Phosphate Clearance: The Effect of Peritoneal Dialysis Modality and Peritoneal Transport Status.

Peritoneal Phosphate Clearance: The Effect of Peritoneal Dialysis Modality and Peritoneal Transport Status. Adv Perit Dial. 2017 Jan;33(2017):6-12 Authors: Davenport A Abstract Hyper- and hypophosphatemia are recognized risk factors for all-cause mortality in peritoneal dialysis (PD) patients. Recent changes have now focused PD solute clearance targets on urea clearance, rather than on larger solutes, including phosphate. We therefore studied peritoneal phosphate clearance in a cohort of PD patients to determine which factors were clinically relevant.We reviewed results from 451 adult PD patients who were attending for their first assessment of peritoneal membrane function [31.2% treated by continuous ambulatory PD (CAPD); 24.2.%, by automated PD (APD); and 44.6% by APD with a daytime exchange]. Demographics, PD adequacy parameters, peritoneal phosphate clearance, and transport status were reviewed.Of the study patients, 119 (26.4%) were hyperphosphatemic, and 59 (30.1%) were hypophosphatemic; 22.2% were fast transporters. Total daily peritoneal phosphate losses were greater for the hyperphosphatemic than for the hypophosphatemic patients [15 mg/ dL (range: 10.5-18.6 mg/dL) vs. 25.7 mg/dL (range: 15.5-29.8 mg/dL), p < 0.01], although peritoneal phosphate clearance was less [2.7 mL/min/1.73 m2 (range: 1.6-4.1 mL/min/1.73 m2) vs. 4.2 mL/ min/1.73 m2 (range: 2.1-4.1 mL/min/1.73 m2), p < 0.001]. Peritoneal phosphate clearance was g...
Source: Advances in Peritoneal Dialysis. Conference on Peritoneal Dialysis - Category: Urology & Nephrology Tags: Adv Perit Dial Source Type: research