054 Immunogenicity to botulinum neotoxins: Long term clinical relevance in aesthetic and therapeutic injections

Without any doubt, Botulinum Toxin is an amazing molecule with diverse clinical effects since the 1970S. The clinical use of Botulinum Toxin Type A and Type B (BONT-A and BONT-B) has revolutionized the practice of medicine over the past 30 years. The safety and effectiveness of injectable Botulinum Toxin have been well established in both aesthetic and medical indications. However to reach the desired endpoints and to maintain the efficacy, the frequency of injections is required. By increasing the numbers of patients without favorable therapeutic responses, a new concern has re-emerged on the immunoresistance and loss of effectiveness to treatment.

Source: Journal of Investigative Dermatology - April 19, 2018 Category: Dermatology Authors: M. Shiri, Z. Shiri, F. Bahrami, S. Shiri, G. Ebrahimi, H. Shiri, B. Shiri, M. Bahrami Tags: Adaptive and Auto-Immunity Source Type: research