Rising diabetes has left 15 MILLION people living with 2 or more serious health problems

The Academy of Medical Sciences warning comes just weeks after Cambridge University researchers found that one in four Britons were living with several health complaints.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news

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Capillary Biomedical is looking to develop a safer more reliable and accurate insulin infusion device. The Irvine, CA-based company has closed on $2.9 million in a series seed financing to help get its SteadiSet infusion set on the market. The Series Seed financing involved several Angel groups, including Tech Coast Angels, New York Angels, HBS Alumni Angels of New York, Pasadena Angels and the Mass Medical Angels, making the financing one of the broadest and most successful syndications among Angel investor groups. Other investors included the ACE Fund, PA Fund and NYA Fund. Financing proceeds will be used for clinical tr...
Source: MDDI - Category: Medical Devices Authors: Tags: Business Tubing Source Type: news
This study is registered with ClinicalTrials.gov, number NCT02453711.FindingsBetween Oct 1, 2015, and Feb 11, 2016, 957 individuals were randomly assigned (102–103 participants per active treatment group and 136 in the pooled placebo group). Mean baseline characteristics included age 47 years, bodyweight 111·5 kg, and BMI 39·3 kg/m2. Bodyweight data were available for 891 (93%) of 957 participants at week 52. Estimated mean weight loss was −2·3% for the placebo group versus −6·0% (0·05 mg), −8·6% (0·1 mg), −11·6% (0·2 mg), −1...
Source: The Lancet - Category: General Medicine Source Type: research
ConclusionsOur results identify a novel PDX1 stress inducible complex (es) that regulates expression of stress and apoptosis genes to govern β cell survival.Graphical abstract
Source: Molecular Metabolism - Category: Endocrinology Source Type: research
Publication date: Available online 17 August 2018Source: Diabetes &Metabolic Syndrome: Clinical Research &ReviewsAuthor(s): Shazia Anjum, Manish Bathla, Saminder Panchal
Source: Diabetes and Metabolic Syndrome: Clinical Research and Reviews - Category: Endocrinology Source Type: research
Disclosed are (N)-methanocarba adenine nucleosides, e.g., of the formula (I): as A3 adenosine receptor agonists, pharmaceutical compositions comprising such nucleosides, and a method of use of these nucleosides, wherein A, a, R2, and R3 are as defined in the specification. These nucleosides are contemplated for use in the treatment a number of diseases, for example, inflammation, cardiac ischemia, stroke, asthma, diabetes, and cardiac arrhythmias. Also disclosed are conjugates comprising a dendrimer and one or more ligands, which are functionalized congeners of an agonist or antagonist of a receptor of the G-protein couple...
Source: NIDDK Research Resources - Category: Endocrinology Source Type: research
This study aimed to explore the changes in brain structure in the diabetic rats with and without cognitive impairment. Morris water maze method was used for screening the diabetic rats with/without cognitive impairment. These diabetic rats and controls were imaged using magnetic resonance imaging that segmented into gray and white matter, which was further analyzed using voxel-based morphology (VBM) and regions of interest (ROI) based image retrieval. The ROI results showed that the whole brain volume decreased in diabetic rats with/without cognitive impairment as compared to the control (P 
Source: Neuroscience Letters - Category: Neuroscience Source Type: research
Startup ValenTx has attracted nearly $10.3 million from 32 investors, according to a filing with the Securities &Exchange Commission. The Maple Grove, Minn. company is developing a removable gastric bypass device as an alternative to Roux-en-Y gastric bypass surgery. It raised $10,271,050 in the round begun July 18, 2018. The ValenTx endoluminal bypass therapy mimics the attributes of a Roux-en-Y gastric bypass and is implanted through a non-surgical, endoscopic procedure, according to the company’s website. This procedure does not require gastric stapling or permanent changes to the patient&r...
Source: Mass Device - Category: Medical Devices Authors: Tags: Blog Business/Financial News Diabetes Endoscopic / Arthroscopic Securities & Exchange Commission (SEC) valentx Source Type: news
Conclusions: While the number of identified studies was not large, none reported negative impacts of mHealth on selected outcomes. Future studies on mHealth should design interventions with a greater variety of targeted functions and should adopt more rigorous methodologies to strengthen the evidence for its effectiveness in chronic disease management. PMID: 30109152 [PubMed]
Source: Healthcare Informatics Research - Category: Information Technology Tags: Healthc Inform Res Source Type: research
Kale and Korenstein in BMJ give a good overview of the subject. There is a cognitive bias, not just in medicine but in people in general, I think, in favor of " doing something. " We like to feel as though we're in control. We don't want to get cancer, or diabetes, or heart disease, so if we think there might be something we can do to improve our odds, we're likely to go for it.Often, however, we can do more harm than good by our actions. But other cognitive biases make that hard to notice. Obviously, if we don't get cancer, we won'tknow that we wouldn't have gotten it anyway. We're likely to believe that the pro...
Source: Stayin' Alive - Category: American Health Source Type: blogs
In cases of severe hypoglycemia, an intramuscular injection of glucagon remains the preferred method of treatment.1 Unfortunately, in many states regulatory polices prevent EMT-Basics from being able to administer or carry glucagon, which makes treating such patients experiencing severe hypoglycemia with loss of consciousness far more complicated  and slower than necessary. In addition to the unavailability of glucagon, many EMTs aren’t permitted to perform blood glucose testing (i.e., fingersticks), which makes the identification and treatment of hypoglycemia even more challenging. Severe hypoglycemic events re...
Source: JEMS Patient Care - Category: Emergency Medicine Authors: Tags: Exclusive Articles Patient Care Source Type: news
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