Development of the Vinylogous Pictet-Spengler Cyclization and Total Synthesis of ( ±)-Lundurine A.

Development of the Vinylogous Pictet-Spengler Cyclization and Total Synthesis of (±)-Lundurine A.
Angew Chem Int Ed Engl. 2018 Apr 16;:
Authors: Nash A, Qi X, Maity P, Owens K, Tambar UK
Abstract
A novel vinylogous Pictet-Spengler cyclization has been developed for the generation of indole annulated medium sized rings. The method enables synthesis of tetrahydro-azocinoindoles with a fully substituted carbon center, which is prevalent in many biologically active alkaloids. The strategy has been applied to the total synthesis of (±)-lundurine A.
PMID: 29663602 [PubMed - as supplied by publisher]

Source: Angewandte Chemie - April 16, 2018 Category: Chemistry Authors: Nash A, Qi X, Maity P, Owens K, Tambar UK Tags: Angew Chem Int Ed Engl Source Type: research