Comedication of Valproic Acid Is Associated With Increased Metabolism of Clozapine

Conclusions
Comedication with valproic acid accelerated metabolism of clozapine with predominant effects on the degradation of norclozapine. Therapeutic drug monitoring should be applied to guide individual patient responses upon initiation of comedication.

Source: Journal of Clinical Psychopharmacology - April 18, 2018 Category: Psychiatry Tags: Original Contributions Source Type: research