Steroid-Induced Bone Loss Better Treated With Denosumab? Steroid-Induced Bone Loss Better Treated With Denosumab?
Denosumab found to be superior to risedronate in the treatment of steroid-induced osteoporosis at 12 months, at least in terms of BMD, among patients starting steroid therapy or those who remained on it.Medscape Medical News
Conclusion: The current study provides the first evidence regarding the status of frailty in older Chinese adults with hypertension.
CONCLUSIONS: There are disordered metabolic pathways and imbalanced bone synthetic materials and regulatory substances in diabetic patients with bone metabolic abnormality. These metabolic abnormalities could be the specific indicators in early diagnosis of diabetic osteoporosis. PMID: 33015802 [PubMed - in process]
Conclusion: Liver steatosis and NAFLD with fibrosis were associated with frailty. NAFLD with fibrosis exceeded multimorbidity in the prediction of frailty, suggesting the former as an indicator of metabolic age in PLWH.
The prospect of an increase in ageing population and incidence of diabetes potentially increases the number of amputees in the future1. Hip fractures in lower limb amputees have been reported sporadically in literature2. Amputees suffer from accelerated bone density loss regardless of their age and are at increased risk of osteoporosis and fragility fractures of the hip2,3. This also increases the risk of other co-morbidities such as pressure ulcers and infection if the treatment is delayed4. Hip fractures amongst lower limb amputees though uncommon, pose a management challenge with regards to the surgical approach and tec...
This article provides an overview of EMRI activities during a quarter of a century.
CONCLUSIONS: Although many factors have been reported as influencing the union rate after anterior odontoid screw placement for Anderson type II fractures, duration from injury to surgery> 7 days appears to be the most relevant, resulting in a 48 times higher risk for nonunion. Early surgery appears to be associated with better radiological outcomes, as reported by orthopedic surgeons in other districts. Prospective comparative clinical trials are needed to confirm these results. PMID: 33007754 [PubMed - as supplied by publisher]
AbstractThe COVID-19 pandemic is an extraordinary global emergency that has led to the implementation of unprecedented measures in order to stem the spread of the infection. Internationally, governments are enforcing measures such as travel bans, quarantine, isolation, and social distancing leading to an extended period of time at home. This has resulted in reductions in physical activity and changes in dietary intakes that have the potential to accelerate sarcopenia, a deterioration of muscle mass and function (more likely in older populations), as well as increases in body fat. These changes in body composition are assoc...
CONCLUSION: OVX plus STZ induced more serious bone impairment than OVX alone, which involves the IGF-1R/β-catenin signaling axis in the pathogenesis. This may provide a potential target for treatment of postmenopausal diabetic osteoporosis. PMID: 33000666 [PubMed - as supplied by publisher]
A 78-year-old lady presented with a 1-week history of left ankle pain and redness with fever. There was no preceding trauma. She had a past medical history of well-controlled diabetes, hypertension and osteoporosis complicated by a left neck of femur fracture 3 years ago, which was managed conservatively.
Conclusions: ABL is an effective and well-tolerated treatment for women with postmenopausal osteoporosis at high risk for fracture. Its therapeutic effects are sustained with subsequent ALN therapy. PMID: 32969719 [PubMed - as supplied by publisher]