An unusual presentation of a common condition: Allergic contact dermatitis
International Wound Journal, EarlyView.
ConclusionIn this racially diverse cohort, higher 2nd trimester n-6 PUFAs were associated with atopic dermatitis in children of women with atopy. PUFAs may represent a modifiable risk factor for atopic dermatitis, particularly in individuals with a familial predisposition.
Authors: Ludwig CM, Krase JM, Price KN, Lio PA, Shi VY Abstract The treatment of moderate-severe atopic dermatitis (AD) has traditionally relied upon the off-label use of systemic immunosuppressants such as cyclosporine (CsA), methotrexate (MTX), and mycophenolate mofetil (MMF). However, significant side effects may arise due to the less-targeted nature of these immunosuppressant and therefore chronic usage is limited. AD patients taking immunosuppressants are candidates for dupilumab treatment for its desirable efficacy and favorable side effect profile. However, there exists a gap in clinical knowledge on how to ...
Conclusions: It seems that the colonisation of the lesioned skin, healthy skin and the anterior nares by S. aureus is related with higher tIgE serum concentration, which translates to more severe course of the disease. Significantly increased SEA-IgE and SEB-IgE concentrations were observed in the patients whose tIgE serum concentration was statistically higher. PMID: 31616226 [PubMed]
Authors: Jeziorkowska R, Rożalski M, Skowroński K, Samochocki Z Abstract Introduction: Positive skin prick tests (SPT) results with protein allergens are the minor Hanifin and Rajka's atopic dermatitis (AD) criterion. In adults, they mainly concern aeroallergens. The inflammation of skin often prevents SPT, but does not exclude the assessment of serous specific immunoglobulin E (sIgE) concentrations. Aim: To assess usefulness of testing AD patients to aeroallergens with SPT and sIgE concentrations, and the correlation of these results and the clinical AD course. Material and methods: In 286 AD patients, t...
Conclusions: There may be widespread and severe ACD due to the use of nitrofurazone. Topical nitrofurazone should not be applied on damaged skin as sensitization may develop. Patients and physicians should be aware of the ACD risk associated with topical nitrofurazone, which is also commonly used as self-medication, physicians should take a detailed history of the drug use and products containing nitrofurazone should not be used in conditions where skin integrity is not intact, whenever possible. PMID: 31616212 [PubMed]
The lipids covalently bound to the cornified envelope of corneocytes are essential for the human skin barrier (Swartzendruber et al., 1987). Together with the unbound lipids they form a matrix regulating the permeability for water and pathogens through the stratum corneum (SC). Three main lipid classes are observed in the SC: sterols, fatty acids, and ceramides. Bound ceramides are a subset of the unbound ceramides and have an ultra-long omega-hydroxyl chain (OCer)(Farwanah et al., 2007, Hill et al., 2006).
Capsule Summary: Ruxolitinib cream improved Eczema Area Severity Index and Investigator ’s Global Assessment responses in patients with atopic dermatitis (AD), with rapid, sustained improvement in itch. Ruxolitinib cream may offer a novel and effective treatment for AD.
Atopic dermatitis (AD) is a chronic, pruritic, inflammatory skin disease characterized by a type 2 cytokines secreted by T helper 2 (Th2) cells and group 2 innate lymphoid cells (ILC2s). Despite a high degree of heterogeneity, AD is still explained by type 2 immunity, and the role of interleukin (IL)-17A, which is increased in acute, pediatric, or Asian patients with AD, remains poorly understood. Here, we aimed to investigate the role of IL-17A-producing ILC3s, which are unexplored immune cells, in the pathogenesis of AD.
CONCLUSION AND CLINICAL IMPORTANCE: This study demonstrates that a shorter EDT is possible if the allergic pruritus and inflammation are initially controlled with a short course of glucocorticoids. This shortened trial is likely to improve owner adherence and facilitate the diagnosis of food allergy. PMID: 31617265 [PubMed - as supplied by publisher]
Conclusions: Hair and scalp disorders vary greatly with different demographic areas. In this region of the world, we came across cases of PN due to religious practices. SD was the most prevalent disorder as seen elsewhere. Trichotillomania noted in such a young child was not as a mere habit (as popularly believed), rather an act of anger. Hence, with this study, we want to emphasize the role of detailed history and examination, besides outlining the spectrum of disorders in this age group.