General synthesis of pyrido[1,2-a]indoles via Pd-catalyzed cyclization of o-picolylbromoarenes

Publication date: Available online 7 March 2018 Source:Journal of Organometallic Chemistry Author(s): Padon Chuentragool, Zhou Li, Katrina Randel, Faraj Mahchi, Ishmael Ochi, Shadi Assaf, Vladimir Gevorgyan An efficient Pd-catalyzed cyclization of o-picolylbromoarenes into pyridoindoles has been developed. This novel transformation, which proceeds through a not common for Pd catalysis L-to X-type pyridine ligand swap, provides an efficient route to aryl-, as well as to cyanopyrido[1,2-a]indoles, not easily accessible by existing cyclization methods. Graphical abstract

Source: Journal of Organometallic Chemistry - March 8, 2018 Category: Chemistry Source Type: research