CCL20/CCR6-mediated migration of regulatory T cells to the Helicobacter pylori-infected human gastric mucosa

Conclusions
As well as increasing Treg numbers, H pylori infection induces a change in their characteristics. Expression of CCR6, CXCR1 and CXCR2 probably enables their migration towards CCL20 and IL-8 in the infected gastric mucosa. Such qualitative changes may also explain how H pylori protects against some extragastric inflammatory disorders.

Source: Gut - September 2, 2014 Category: Gastroenterology Authors: Cook, K. W., Letley, D. P., Ingram, R. J. M., Staples, E., Skjoldmose, H., Atherton, J. C., Robinson, K. Tags: Open access Helicobacter pylori Source Type: research