Synthesis of a new bulky phosphite ligand and its application in the enantioselective hydrogenation

Publication date: Available online 24 February 2018 Source:Journal of Organometallic Chemistry Author(s): Marina V. Sokolovskaya, Sergey E. Lyubimov, Igor S. Mikhel, Kirill P. Birin, Vadim A. Davankov A new bulky phosphite ligand was synthesized and tested in the asymmetric Rh-catalyzed hydrogenation of a series of substrates, including dimethyl itaconate (up to 95% ee), α- and β-dehydroamino acid derivatives (up to 88% and 76% ee, respectively). In the Ir-catalyzed hydrogenation of 2-methylindole, the use of iodine as an additive led to a significant increase in the enantioselectivity and conversion. The best result (64% ee) was obtained with [Ir(COD)Cl]2 as precatalyst. Graphical abstract

Source: Journal of Organometallic Chemistry - February 25, 2018 Category: Chemistry Source Type: research