Researchers describe how diabetes drugs activate their target

The interaction mechanisms between diabetes drugs and their receptors have been described by researchers, a study inNature reports. This could potentially lead to developing novel drugs to treat diabetes and obesity.Medical Xpress
Source: Society for Endocrinology - Category: Endocrinology Source Type: news

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Authors: Karczewski J, Śledzińska E, Baturo A, Jończyk I, Maleszko A, Maleszko A, Samborski P, Begier-Krasińska B, Dobrowolska A Abstract The prevalence of obesity has recently increased dramatically and has contributed to the increasing prevalence of various pathological conditions, including type 2 diabetes mellitus, nonalcoholic fatty liver disease, asthma, various types of cancer, cardiovascular and neurodegenerative diseases, and others. Accumulating evidence points to localized inflammation in adipose tissue, which, in turn, promotes systemic low-grade inflammation as a primary force contributing to the d...
Source: European Cytokine Network - Category: Molecular Biology Tags: Eur Cytokine Netw Source Type: research
Authors: Bastard JP, Fellahi S, Audureau É, Layese R, Roudot-Thoraval F, Cagnot C, Mahuas-Bourcier V, Sutton A, Ziol M, Capeau J, Nahon P Abstract An obesity-related altered adipose tissue secretion is suggested as a risk factor for hepatocellular carcinoma (HCC) in patients with hepatitis C virus (HCV) cirrhosis. However, no prospective study has yet examined the predictive value of circulating adipokines and immuno-inflammatory biomarkers regarding this risk. This was a case-control study nested in a prospective French national cohort of HCV-infected patients with biopsy-proven compensated cirrhosis. We se...
Source: European Cytokine Network - Category: Molecular Biology Tags: Eur Cytokine Netw Source Type: research
The objective of this comprehensive review is to summarize and discuss the available evidence of how adipose tissue inflammation affects insulin sensitivity and glucose tolerance. Low-grade, chronic adipose tissue inflammation is characterized by infiltration of macrophages and other immune cell populations into adipose tissue, and a shift toward more proinflammatory subtypes of leukocytes. The infiltration of proinflammatory cells in adipose tissue is associated with an increased production of key chemokines such as C-C motif chemokine ligand 2, proinflammatory cytokines including tumor necrosis factor α and interle...
Source: Comprehensive Physiology - Category: Physiology Tags: Compr Physiol Source Type: research
Publication date: Available online 15 December 2018Source: European Polymer JournalAuthor(s): Abhishek Gupta, Marek Kowalczuk, Wayne Heaselgrave, Stephen T. Britland, Claire Martin, Iza RadeckaAbstractWound treatment has increased in importance in the wound care sector due to the pervasiveness of chronic wounds in the high-risk population including, but not limited to, geriatric population, immunocompromised and obese patients. Furthermore, the number of people diagnosed with diabetes is rapidly growing. According to the World Health Organization (WHO), the global diabetic occurrence has increased from 4.7% in 1980 to 8.5%...
Source: European Polymer Journal - Category: Chemistry Source Type: research
Conclusion: Higher NLR in patients with Bell's palsy was associated with longer recovery time. NLR may be prognostic of recovery time in patients with Bell's palsy. PMID: 30545211 [PubMed - as supplied by publisher]
Source: Clinical and Experimental Otorhinolaryngology - Category: ENT & OMF Tags: Clin Exp Otorhinolaryngol Source Type: research
The objective of this systematic review was to search for scientific evidence regarding the impact of periodontal therapy on serum levels of interleukin 6 (IL-6) in type 2 diabetics. A survey was conducted in five databases. Two researchers read titles and abstracts for initial selection and full text for inclusion. Data extraction and methodological quality assessment were performed. Four hundred and fifty-five studies were identified and 15 were included. Significant divergence on the effect of periodontal intervention on IL-6 levels in diabetics was observed among studies. The evaluation results of studies that controll...
Source: International Journal of Periodontics and Restorative Dentistry - Category: Dentistry Tags: Int J Periodontics Restorative Dent Source Type: research
This study aimed to measure the effects of duodenal-jejunal exclusion (DJE) on glycometabolism in non-obese type 2 diabetic rats, and to investigate the mechanisms. Goto–Kakizaki(GK) rats and Sprague–Dawley(SD) rats were divided into DJE operation groups and sham operation groups respectively. The glucose relative parameters were measured before and after operation. 8 weeks postoperation, the levels of the key regulators of intestinal gluconeogenesis and the crucial proteins of hepatic insulin signaling were evaluated. Postoperatively, the concentration of blood glucose declined and the insulin sensitivity was ...
Source: Canadian Journal of Diabetes - Category: Endocrinology Source Type: research
Publication date: Available online 15 December 2018Source: NeuroImageAuthor(s): Owen A. Williams, Yang An, Lori Beason-Held, Yuankai Huo, Luigi Ferrucci, Bennett A. Landman, Susan M. ResnickAbstractWhite matter microstructure can be measured with diffusion tensor imaging (DTI). While increasing age is a predictor of white matter (WM) microstructure changes, roles of other possible modifiers, such as cardiovascular risk factors, APOE ε4 allele status and biological sex have not been clarified.We investigated 665 cognitively normal participants from the Baltimore Longitudinal Study of Aging (age 50–95, 56.7% fe...
Source: NeuroImage - Category: Neuroscience Source Type: research
In conclusion, both RH and RfH constitute challenges in clinical practice and should be addressed as distinct clinical entities by trained professionals who are capable to identify comorbidities and provide specific, diversified, and individualized treatment. PMID: 30525180 [PubMed - as supplied by publisher]
Source: Jornal Brasileiro de Nefrologia - Category: Urology & Nephrology Tags: J Bras Nefrol Source Type: research
Publication date: Available online 15 December 2018Source: Molecular Aspects of MedicineAuthor(s): Denise Hoch, Martin Gauster, Sylvie Hauguel-de Mouzon, Gernot DesoyeAbstractEarly pregnancy is characterized by a series of complex and tightly regulated events to ultimately establish implantation and early placental development. One of the key events is the opening of the decidual spiral arteries into the intervillous space. It leads to a rise in oxygen tension in the intervillous space and the placenta and will induce transcriptional and translational changes of oxygen-sensitive molecules including antioxidants.Diabetes an...
Source: Molecular Aspects of Medicine - Category: Molecular Biology Source Type: research
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