Researchers describe how diabetes drugs activate their target

The interaction mechanisms between diabetes drugs and their receptors have been described by researchers, a study inNature reports. This could potentially lead to developing novel drugs to treat diabetes and obesity.Medical Xpress
Source: Society for Endocrinology - Category: Endocrinology Source Type: news

Related Links:

CONCLUSION Our study is the first to report that Plt-EVs might provide a feasible product for transfusion in trauma patients to attenuate bleeding, inhibit vascular permeability, and mitigate the endotheliopathy of trauma.
Source: The Journal of Trauma: Injury, Infection, and Critical Care - Category: Orthopaedics Tags: AAST 2018 PODIUM PAPER Source Type: research
Publication date: Available online 22 May 2019Source: Diabetes &Metabolic Syndrome: Clinical Research &ReviewsAuthor(s): Abbas Ali Sangouni, Saeid Ghavamzadeh, Atena JamalzehiAbstractThe global prevalence of Non-alcoholic fatty liver disease (NAFLD) is increasing rapidly. Many studies have been conducted on the treatment of NAFLD; nevertheless, there is still no approved drug treatment for this disease. Although the pathogenesis of NAFLD is not fully understood, but inflammation, insulin resistance, oxidative stress, obesity and dyslipidemia are among the main causes. Epidemiological studies have shown that hypovit...
Source: Diabetes and Metabolic Syndrome: Clinical Research and Reviews - Category: Endocrinology Source Type: research
Conclusions: Patients with RHS who have an elevated NLR have poor outcomes in terms of the H-B grade. Therefore, the NLR may be useful for evaluating the prognosis of patients with RHS.ORL
Source: ORL - Category: ENT & OMF Source Type: research
Metabolic flexibility can be assessed by changes in respiratory exchange ratio (RER) following feeding. Though metabolic flexibility (difference in RER between fasted and fed state) is often impaired in individuals with obesity or type 2 diabetes, the cellular processes contributing to this impairment are unclear.
Source: Metabolism - Clinical and Experimental - Category: Biomedical Science Authors: Source Type: research
AbstractPurpose of ReviewThe purpose of this review is to emphasize the pivotal role of glucagon-like peptide 1 (GLP-1) in tackling the parallel epidemics of obesity and type 2 diabetes (T2DM).Recent FindingsGLP-1-based therapies and in particular GLP-1 receptor agonists (GLP-1 RA) have proven to be effective in lowering blood glucose and decreasing weight. GLP-1 RA not only mitigate these significant medical burdens but also result in weight loss and weight loss independent factors that decrease cardiovascular disease (CVD) and microvascular complications of T2DM, such as diabetic nephropathy.SummaryGLP-1-based therapies ...
Source: Current Obesity Reports - Category: Eating Disorders & Weight Management Source Type: research
Nutrition&Food Science, Ahead of Print. Purpose The enrichment of bread with non-digestible prebiotic ingredients may exert health-promoting effects and provide healthier food choices for those suffering from metabolic diseases, including obesity and diabetes. The purpose of this study was to investigate the effects of ß-glucan and resistant starch incorporation on the glycemic index (GI) and glycemic load (GL) of white bread. Design/methodology/approach Seven different formulations of prebiotic bread were produced using different proportions of ß-glucan (0.8, 1 and 1.2 per cent), resistant starch (5.5, 8 and 1...
Source: Nutrition and Food Science - Category: Nutrition Source Type: research
AbstractSaturated fatty acids are implicated in the development of metabolic diseases, including obesity and type 2 diabetes. There is evidence, however, that polyunsaturated fatty acids can counteract the pathogenic effects of saturated fatty acids. To gain insight into the early molecular mechanisms by which fatty acids influence hypothalamic inflammation and insulin signalling, we performed time-course experiments in a hypothalamic cell line, using different durations of treatment with the saturated fatty acid palmitate, and the omega-3 polyunsaturated fatty acid, docosahexaenoic acid (DHA). Western blot analysis reveal...
Source: Journal of Comparative Physiology B: Biochemical, Systemic, and Environmental Physiology - Category: Physiology Source Type: research
This study investigated whether a newly developed smartphone game delivering individualized exercise and physical activity promotion through an elaborate storyline can generate sustained improvements in daily physical activity (steps/day).Study designThirty-six participants were enrolled in this 24-week RCT between August 2016 and April 2018. After baseline assessment, participants were randomized in equal numbers to the intervention or control condition. Data analysis was performed in May–June 2018.Setting/participantsInactive, overweight type 2 diabetes patients, aged 45–70 years, were recruited through adver...
Source: American Journal of Preventive Medicine - Category: International Medicine & Public Health Source Type: research
Publication date: Available online 22 May 2019Source: American Journal of Preventive MedicineAuthor(s): Jessica L. McCurley, Douglas E. Levy, Eric B. Rimm, Emily D. Gelsomin, Emma M. Anderson, Jenny M. Sanford, Anne N. ThorndikeIntroductionMost Americans spend half their waking hours at work and consume food acquired there. The hypothesis was that the healthfulness of worksite food purchases was associated with employees’ overall diet and health.MethodsParticipants were 602 hospital employees who regularly used worksite cafeterias and enrolled in a health promotion study in 2016–2018. All cafeterias used traffi...
Source: American Journal of Preventive Medicine - Category: International Medicine & Public Health Source Type: research
Although gastric bypass surgery is linked to'myriad health benefits'for those with obesity, an increased fracture risk'is an important factor to discuss with patients,'says the lead author of new study.Medscape Medical News
Source: Medscape FamilyMedicine Headlines - Category: Primary Care Tags: Diabetes & Endocrinology News Source Type: news
More News: Diabetes | Eating Disorders & Weight Management | Endocrinology | Obesity | Study