Neutralization of IL-17C reduces skin inflammation in mouse models of psoriasis and atopic dermatitis

Interleukin-17C (IL-17C) is a functionally distinct member of the IL-17 family that was implicated to play a role in the pathogenesis of psoriasis. Here we confirmed that IL-17C is involved in psoriasis and explored potential roles for IL-17C in atopic dermatitis (AD). An anti-IL-17C antibody, MOR106, was generated that potently and selectively binds to human and mouse IL-17C, thereby inhibiting the binding of IL-17C to its IL-17RE receptor. The antibody inhibited cutaneous inflammation in an IL-23-induced psoriatic-like skin inflammation model.

Source: Journal of Investigative Dermatology - February 20, 2018 Category: Dermatology Authors: Nick Vandeghinste, J ürgen Klattig, Catherine Jagerschmidt, Stéphanie Lavazais, Florence Marsais, Jan D. Haas, Marielle Auberval, Felix Lauffer, Tara Moran, Mate Ongenaert, Maarten Van Balen, Sonia Dupont, Liên Lepescheux, Teresa Garcia, Stefan Härtle Tags: Original Article Source Type: research