A diagnostically challenging case of CD8+ primary cutaneous gamma/delta T-cell lymphoma.

A diagnostically challenging case of CD8+ primary cutaneous gamma/delta T-cell lymphoma.
Dermatol Online J. 2017 Nov 15;23(11):
Authors: Pitch MA, Kim KH, Manning T, Smoller BR, Wong HK, Kaley JR
Abstract
Primary cutaneous gamma/delta T-cell lymphoma (PCγδTCL) is a rare form of cutaneous lymphoma characterized by abnormal clonal proliferation of mature, activated gamma-delta T cells expressing the γδ heterodimer of the T-cell receptor (TCR). As an entity, PCγδTCL has recently undergone diagnostic revision since its introduction in the 2008 WHO classification of cutaneous lymphomas and confirmedin 2016. Nonetheless, diagnosis remains difficult both clinically and histologically, given its broad range of clinical manifestations and immunohistochemical phenotypes. Herein, we present a rare case of CD8+ PCγδTCL with a discussion highlighting theheterogeneity within this entity.
PMID: 29447636 [PubMed - in process]

Source: Dermatol Online J - November 15, 2017 Category: Dermatology Authors: Pitch MA, Kim KH, Manning T, Smoller BR, Wong HK, Kaley JR Tags: Dermatol Online J Source Type: research