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Lena Dunham says she had a total hysterectomy

Lena Dunham says she is coming to terms with her permanent infertility
Source: Health News: CBSNews.com - Category: Consumer Health News Source Type: news

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Semin intervent Radiol 2018; 35: 048-055 DOI: 10.1055/s-0038-1636521Uterine fibroids (leiomyomas) are the most common benign neoplasm of the female pelvis and have a lifetime prevalence exceeding 80% among African American women and approaching 70% among Caucasian women. Approximately 50% of women with fibroids experience symptoms which may include menorrhagia that may result in anemia, bulk symptoms with bladder and bowel dysfunction and abdominal protrusion, dysmenorrhea, and infertility. Hysterectomy remains the most common treatment option for fibroids and concerns have been raised about the overuse of this procedure. ...
Source: Seminars in Interventional Radiology - Category: Radiology Authors: Tags: Review Article Source Type: research
Transplantation of the uterus is required in cases of absolute uterine factor infertility (AUFI), which are caused either because of uterus deficiency (congenital or after a hysterectomy) or existence of non-functional uterus.
Source: The Journal of Urology - Category: Urology & Nephrology Authors: Tags: Transplantation & Vascular Surgery: Renal Transplantation Vascular Surgery I Source Type: research
Uterus transplantation (UTx) has been successfully introduced as a treatment option for women with absolute uterine factor infertility (AUFI). AUFI representing approximately 3% to 5% of the female general population is linked to either congenital uterine agenesis (Mayer-Rokitansky-Küster-Hauser syndrome), major congenital uterine malformation (hypoplastic uterus, fraction of bicornuate/unicornuate uterus), a surgically absent uterus, or an acquired condition (intrauterine adhesions, leiomyoma) linked to uterine malfunction that causes implantation failure or defect placentation. The world’s first clinical uteru...
Source: Transplantation - Category: Transplant Surgery Tags: Reviews Source Type: research
Ms. Dunham said that she had the procedure at age 31, but that doctors were reluctant to perform it on a woman of her age.
Source: NYT Health - Category: Consumer Health News Authors: Tags: Hysterectomies Endometriosis Women and Girls Infertility Uterus National Institute of Child Health and Human Development National Women's Health Network Vogue Dunham, Lena Source Type: news
Authors: Brennan A, Hickey M Abstract Abnormal uterine bleeding refers to any change in the regularity, frequency, heaviness or length of menstruation. There are several potential causes for bleeding disturbance, the two most common being primary endometrial dysfunction and fibroids. Management of abnormal uterine bleeding involves both medical and surgical options and will largely depend on a patient's fertility plans. The use of levonorgestrel-releasing intrauterine devices for heavy menstrual bleeding is increasing in Australia, and they are considered first-line medical management for women accepting of hormona...
Source: Medical Journal of Australia - Category: General Medicine Tags: Med J Aust Source Type: research
Conclusions Except for the risk of premature ovarian failure, a rare adverse effect of combined treatments, both single-agent and multiagent chemotherapy can be safely administered to patients with a desire for childbearing. High-risk patients have worse reproductive outcomes because they undergo hysterectomy more frequently than low-risk patients.
Source: International Journal of Gynecological Cancer - Category: Cancer & Oncology Tags: Gestational Cancer Source Type: research
AbstractSTUDY QUESTIONSAre extracellular vesicles (EVs) in the murine oviduct (oviductosomes, OVS) conserved in humans and do they play a role in the fertility ofPmca4−/ − females?SUMMARY ANSWEROVS and their fertility-modulating proteins are conserved in humans, arise via the apocrine pathway, and mediate a compensatory upregulation of PMCA1 (plasma membrane Ca2+-ATPase 1) inPmca4−/ − female mice during proestrus/estrus, to account for their fertility.WHAT IS KNOWN ALREADYRecently murine OVS were identified and shown during proestrus/estrus to express elevated levels of PMCA4 which they can deliver ...
Source: Molecular Human Reproduction - Category: Molecular Biology Source Type: research
AbstractSTUDY QUESTIONAre the large cells derived from cultured DEAD box polypeptide 4 (DDX4)-positive oogonial stem cells (OSCs), isolated from the ovarian cortex of non-menopausal and menopausal women, oocyte-like cells?SUMMARY ANSWERUnder appropriate culture conditions, DDX4-positive OSCs from non-menopausal and menopausal women differentiate into large haploid oocyte-like cells expressing the major oocyte markers growth differentiation factor 9(GDF-9) and synaptonemal complex protein 3 (SYCP3) and then enter meiosis.WHAT IS KNOWN ALREADYThe recent reports of OSCs in the ovaries of non-menopausal and menopausal women su...
Source: Human Reproduction - Category: Reproduction Medicine Source Type: research
(Abstracted from Hum Reprod 2017;32(10):2036–2041) Uterine tumors are a public health issue because of their prevalence in women and their connection to menstrual disorders, anemia, pelvis pain, pregnancy loss, and infertility. Treatment of symptomatic fibroids includes open myomectomy or hysterectomy, which have higher morbidity rates, longer hospital stays, and more disruption of daily life.
Source: Obstetrical and Gynecological Survey - Category: OBGYN Tags: Gynecology: Normal and Abnormal Menstrual Cycles Source Type: research
ConclusionThe survey demonstrated that myomectomy by hysteroscopy or laparoscopy has similar risks of sarcoma with an estimated incidence of 0.07%, much lower than that by laparoscopic hysterectomy and subtotal hysterectomy. Hence, for young patients with myoma infertility problem and low risk for LMS, myomectomy by MIS can be the first option of treatment. The fact that only 12.5% (216/1728) of uterine sarcoma cases are operated laparoscopically demonstrates the surgeons ’ awareness and alertness about LMS and the potential of spreading sarcomatous cells after myoma/uterus power morcellation.
Source: Gynecological Surgery - Category: OBGYN Source Type: research
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