Two Drugs Offer Hope Against a Tough-to-Treat Prostate Cancer

Source: Cancercompass News: Other Cancer - Category: Cancer & Oncology Source Type: news

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PROSTATE cancer happens when problems in an area of the male reproductive system cause cells to start dividing uncontrollably. You ’re more at risk of prostate cancer if you’re older, overweight or have a family history of the cancer. However, eating this red food can help you prevent the condition.
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
Authors: Fantony JJ, Howard LE, Csizmadi I, Armstrong AJ, Lark AL, Galet C, Aronson WJ, Freedland SJ Abstract AIM: To test if Ki67 expression is prognostic for biochemical recurrence (BCR) after radical prostatectomy (RP). METHODS: Ki67 immunohistochemistry was performed on tissue microarrays constructed from specimens obtained from 464 men undergoing RP at the Durham and West LA Veterans Affairs Hospitals. Hazard ratios (HR) for Ki67 expression and time to BCR were estimated using Cox regression. RESULTS: Ki67 was associated with more recent surgery year (p 
Source: Future Medicine: Biomarkers in Medicine - Category: Internal Medicine Tags: Biomark Med Source Type: research
In this study, we attempt to discriminate prostate cancer from non-cancer in a cohort of plasma samples, using the Imubind ELISA assay. In this cohort, PAI-1 levels are higher in prostate cancer patients than healthy donors; uPA levels are higher in healthy donors than prostate cancer patients; and the uPA/PAI-1 ratio is higher in healthy donors than in prostate cancer patients. To date, and across three prostate sample types, i.e. transurethral resection tissue, needle biopsies, and blood plasma, data have been disparate. Given the inconsistency, a malignancy index was created by dividing the product of three biomarkers [...
Source: Discovery Medicine - Category: Research Tags: Discov Med Source Type: research
Publication date: Available online 15 June 2018 Source:Pharmacology & Therapeutics Author(s): Wei Wang, Zhao-Xia Chen, Dong-Yu Guo, Ya-Xiong Tao Regulation of prostate cancer by androgen and androgen receptor (AR), and blockade of AR signaling by AR antagonists and steroidogenic enzyme inhibitors have been extensively studied. G protein-coupled receptors (GPCRs) are a family of membrane receptors that regulate almost all physiological processes. Nearly 40% of FDA-approved drugs in the market target GPCRs. A variety of GPCRs that mediate reproductive function have been demonstrated to be involved in the regulation of p...
Source: Pharmacology and Therapeutics - Category: Drugs & Pharmacology Source Type: research
Publication date: July 2018 Source:European Urology Supplements, Volume 17, Issue 5 Author(s): A.K. Bhuvanagiri, S. Kannan, W.S.M. Williams, D. Gundupalli, D. Fegredo, U. Hassan, B. Allen, B. Robinson, S. Arshad, T. Nadeem, E. Edge, A. Tivey, M. Thangavelu, E.K. Ahiaku, K. Alexandrou
Source: European Urology Supplements - Category: Urology & Nephrology Source Type: research
Publication date: July 2018 Source:European Urology Supplements, Volume 17, Issue 5 Author(s): A. Patasius, A. Kaceniene, A. Ulys, G. Smailyte
Source: European Urology Supplements - Category: Urology & Nephrology Source Type: research
Publication date: July 2018 Source:European Urology Supplements, Volume 17, Issue 5 Author(s): A.K. Bhuvanagiri, S. Kannan, D. Gundupalli, D. Fegredo, T. Nadeem, A. Tivey, E. Edge, B. Allen, B. Robinson, M. Thangavelu, E.K. Ahiaku, K. Alexandrou
Source: European Urology Supplements - Category: Urology & Nephrology Source Type: research
Publication date: July 2018 Source:European Urology Supplements, Volume 17, Issue 5 Author(s): M. Barisiene, D. Stanciute, A. Bakavicius, J. Jurkeviciene, A. Zelvys, A. Ulys, F. Jankevicius
Source: European Urology Supplements - Category: Urology & Nephrology Source Type: research
Publication date: July 2018 Source:European Urology Supplements, Volume 17, Issue 5 Author(s): S. Semenov, S. Krasny, A. Minich
Source: European Urology Supplements - Category: Urology & Nephrology Source Type: research
Publication date: July 2018 Source:European Urology Supplements, Volume 17, Issue 5 Author(s): G. Sperga, M. Jakubovskis, M. Sperga, L. RÄ“dmanis, V. Lietuvietis
Source: European Urology Supplements - Category: Urology & Nephrology Source Type: research
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