High flu rate continues to put pressure on GPs

GP practices are continuing to face high rates of consultations for flu, official NHS data confirm.
Source: GP Online News - Category: Primary Care Tags: Influenza Source Type: news

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The TWiVerati follow up on the Ebola virus outbreak, virulence of Ebola-Makona, and reveal how a parasitoid is revealed to hyperparasitoids, and binding of influenza virus to a calcium ion channel to mediate influenza virus entry. <span data-mce-type=”bookmark” style=”display: inline-block; width: 0px; overflow: hidden; line-height: […]
Source: virology blog - Category: Virology Authors: Tags: This Week in Virology A82V caterpillar ebola virus endocytosis hyperparasitoid influenza virus ion channel parasitoid wasp polydnavirus viral virulence viruses voltage gated calcium channel Source Type: blogs
Conclusion Early detection and referral, and early antiviral treatment with a strict control of nosocomial spread is essential in patients with cirrhosis during epidemic influenza.
Source: Journal of Clinical and Experimental Hepatology - Category: Gastroenterology Source Type: research
We reported a 28-year-old healthy woman presented with subacute onset ascending muscle weakness 2 weeks after an annual influenza vaccination. Cerebral Spinal Fluid study showed normal cell counts with elevated protein and nerve conduction study showed reduced diffuse compound muscle action potential amplitudes suggesting a diagnosis of Guillain–Barré syndrome. Despite treatment using intravenous immunoglobulin, her condition continued to get worse with new bulbar and respiratory muscle weakness. Eventually, the diagnosis of anti–single recognition particle–mediated necrotizing myopathy was made ba...
Source: Journal of Clinical Neuromuscular Disease - Category: Neurology Tags: Case Review Source Type: research
Publication date: July 2018 Source:Microbial Pathogenesis, Volume 120 Author(s): Cong Zhang, Jiangfei Zhou, Kairui Cai, Wufan Zhang, Chengshui Liao, Chen Wang Thymosin α1 (Tα1) and bursin-like peptide (BLP) are both immunopotentiators. In order to investigate adjuvant of thymosin α1-bursin-like peptide (Tα1-BLP), we cloned the gene of Tα1-BLP and provided evidence that the gene of Tα1-BLP in a recombinant prokaryotic expression plasmid was successfully expressed in E. coli BL21. To evaluate the immune adjuvant properties of Tα1-BLP, chickens were immunized with Tα1-BLP combi...
Source: Microbial Pathogenesis - Category: Infectious Diseases Source Type: research
Binghui Xia, Jiansheng Lu, Rong Wang, Zhixin Yang, Xiaowei Zhou, Peitang Huang
Source: Frontiers in cellular and infection microbiology - Category: Microbiology Source Type: research
Contributors : Shi Shaohua ; Peng DaxinSeries Type : Expression profiling by high throughput sequencingOrganism : Gallus gallusH5N1 highly pathogenic avian influenza (HPAI) has raised global concern for causing huge economic losses in poultry industry. By using reversal genetic technical, we have rescued a H5 wild-type virus rS and its NS1-truncated virus S-NS99, harboring only 99 amino acids in the amino terminus of NS1. We then used a high-throughput RNA-seq method to analyze host and pathogen transcriptomes in the lungs of chickens infected with rS and S-NS99. Sequenced numbers of viral transcripts and expression levels...
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Gallus gallus Source Type: research
Since the novel avian influenza A H7N9 virus emerged in March 2013,1 it has triggered five epidemics of human infections in China.2-4 This virus causes severe and fatal respiratory diseases in humans, and many people infected with the H7N9 virus died due to severe pneumonia and its complications.5 A total of 1,564 laboratory-confirmed cases of human infection have been reported to the World Health Organization (WHO).6 There were 135, 316, 226 and 121 cases reported in waves 1-4, respectively, with a declining trend.
Source: Journal of Infection - Category: Infectious Diseases Authors: Source Type: research
This study provides data from a multicenter evaluation of 1,612 prospectively collected NPS samples, with performance compared to that of the FilmArray RP or PCR and sequencing. The overall percent agreement between the FilmArray RP2 and the comparator testing was 99.2%. The RP2 demonstrated a positive percent agreement of 91.7% or greater for detection of all but three analytes: coronavirus OC43, B. parapertussis, and B. pertussis. The FilmArray RP2 also demonstrated a negative percent agreement of ≥93.8% for all analytes. Of note, the adenovirus assay detects all genotypes, with a demonstrated increase in sensitivity....
Source: Journal of Clinical Microbiology - Category: Microbiology Authors: Tags: Virology Source Type: research
Anti-influenza effect and action mechanisms of the chemical constituent gallocatechin-7-gallate from Pithecellobium clypearia Benth, Published online: 25 May 2018; doi:10.1038/s41401-018-0030-xAnti-influenza effect and action mechanisms of the chemical constituent gallocatechin-7-gallate from Pithecellobium clypearia Benth
Source: Acta Pharmacologica Sinica - Category: Drugs & Pharmacology Authors: Source Type: research
This study aimed to further illuminate the anti-inflammatory effects and mechanism of the total flavonoids (ASTF) from Artemisia scoparia Waldst. et Kit. In vitro, RAW 264.7 cells were pretreated with ASTF 1 h before stimulation with LPS (1 μg/mL) for 24 h. Then, the concentrations of NO, PGE2, TNF-α, IL-6 and MCP-1 in the medium were determined. Intracellular oxidative stress was detected using DCFH-DA. Immunofluorescent analysis, western blot and qRT-PCR were carried out to illuminate the mechanism of anti-inflammatory effects of ASTF. In vivo, mice were given an intragastric administration of ASTF 1 h b...
Source: Biomedicine and Pharmacotherapy - Category: Drugs & Pharmacology Source Type: research
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