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Results From Phase 3 XGEVA ® (Denosumab) Study In Patients With Multiple Myeloma Published In The Lancet Oncology

In this study, XGEVA successfully met the primary endpoint, demonstrating non-inferiority to zoledronic acid in delaying the time to first on-study skeleta...
Source: Amgen News Release - Category: Pharmaceuticals Tags: Uncategorized Source Type: news

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Authors: Kumar SK Abstract The most recent NCCN Guidelines for Multiple Myeloma include a ranking of the many treatment options for various settings as "preferred," "other," and "useful in certain circumstances." For patients eligible for autologous stem cell transplant (ASCT), the preferred regimen remains bortezomib/lenalidomide/dexamethasone (category 1) or bortezomib/cyclophosphamide/dexamethasone. Upfront ASCT also remains a preferred strategy for patients who are transplant-eligible, despite highly effective newer agents such as induction therapy. Double (tandem) ASCT may benefit...
Source: Journal of the National Comprehensive Cancer Network : JNCCN - Category: Cancer & Oncology Tags: J Natl Compr Canc Netw Source Type: research
This article summarizes the results of 30 y of follow-up of cancer and noncancer effects in Ukrainian cleanup workers after the Chornobyl accident. The number of power plant employees and first responders with acute radiation syndrome under follow-up by the National Research Center for Radiation Medicine decreased from 179 in 1986–1991 to 105 in 2011–2015. Cancers and leukemia (19) and cardiovascular diseases (21) were the main causes of deaths among acute radiation syndrome survivors (54) during the postaccident period. Increased radiation risks of leukemia in the Ukrainian cohort of 110,645 cleanup workers ex...
Source: Health Physics - Category: Radiology Tags: Review Papers Source Type: research
This article summarizes the results of 30 y of follow-up of cancer and noncancer effects in Ukrainian cleanup workers after the Chornobyl accident. The number of power plant employees and first responders with acute radiation syndrome under follow-up by the National Research Center for Radiation Medicine decreased from 179 in 1986-1991 to 105 in 2011-2015. Cancers and leukemia (19) and cardiovascular diseases (21) were the main causes of deaths among acute radiation syndrome survivors (54) during the postaccident period. Increased radiation risks of leukemia in the Ukrainian cohort of 110,645 cleanup workers exposed to low...
Source: Health Physics - Category: Physics Authors: Tags: Health Phys Source Type: research
Abstract Knowledge of genetic mutations and how these affect patient outcomes is rapidly expanding in the care of individuals diagnosed with multiple myeloma (MM). Genetic analysis of bone marrow biopsies now provides information about diagnosis,response to treatment, and prognosis. Oncology nurses need to understand the science and meaning of bone marrow biopsy reports, including the implications of genetic alterations and minimal residual disease. This will allow them to provide care, support, and education related to MM and its treatment to patients and their families. PMID: 29781462 [PubMed - in process]
Source: Clinical Journal of Oncology Nursing - Category: Nursing Authors: Tags: Clin J Oncol Nurs Source Type: research
Publication date: Available online 3 May 2018 Source:European Journal of Radiology Author(s): Christoph Schabel, Marius Horger, Sara Kum, Katja Weisel, Jan Fritz, Sorin D. Ioanoviciu, Georg Bier
Source: European Journal of Radiology - Category: Radiology Source Type: research
The pattern of the M-protein in smoldering myeloma over the time: an evolving risk factor, Published online: 23 May 2018; doi:10.1038/s41375-018-0156-3The pattern of the M-protein in smoldering myeloma over the time: an evolving risk factor
Source: Leukemia - Category: Hematology Authors: Source Type: research
Conclusion This study suggests that tumoral spinal fractures with posterior vertebral wall involvement can be successfully and safely treated by CT- and fluoroscopy-guided percutaneous vertebroplasty.
Source: European Journal of Radiology - Category: Radiology Source Type: research
Integrated Myeloma Management for Transplant-Eligible Patients: The Conjunction of Novel Therapeutic Platforms, Innovative Agents, and HCT
Source: PeerView CME/CE Video Podcast - Oncology - Category: Cancer & Oncology Authors: Tags: Science, Medicine Source Type: video
Source: Clinical Lymphoma, Myeloma and Leukemia - Category: Hematology Source Type: research
Source: Clinical Lymphoma, Myeloma and Leukemia - Category: Hematology Source Type: research
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