Bioactive hydroanthraquinones from endophytic fungus Nigrospora sp. BCC 47789

Publication date: April 2018 Source:Phytochemistry Letters, Volume 24 Author(s): Jittra Kornsakulkarn, Wilunda Choowong, Pranee Rachtawee, Nattawut Boonyuen, Surisa Kongthong, Masahiko Isaka, Chawanee Thongpanchang A new hydroanthraquinone, nigrosporone A (1), and a new naturally occurring nigrosporone B (2), together with eleven known compounds, were isolated from an endophytic fungus, Nigrospora sp. BCC 47789. The structure of nigrosporone A was confirmed by X-ray crystallographic analysis. The absolute configurations of nigrosporone B were determined by the modified Mosher’s method. Nigrosporone B exhibited a broad range of biological activities including antimalarial, antitubercular, antibacterial and cytotoxic activities, while nigrosporone A and Fusaquinon A showed only cytotoxic activity. Graphical abstract

Source: Phytochemistry Letters - February 3, 2018 Category: Chemistry Source Type: research