Tumor suppressor BTG1 limits activation of BCL6 expression downstream of ETV6-RUNX1

• Loss of BTG1 potentiates ETV6-RUNX1-mediated self-renewal capacity• Tumor suppressor BTG1 limits activation of BCL6 by ETV6-RUNX1• BCL6 enhances the clonogenicity of primitive B lymphoid progenitors

Source: Experimental Hematology - February 2, 2018 Category: Hematology Authors: Esther Tijchon, Liesbeth van Emst, Laurensia Yuniati, Dorette van Ingen Schenau, Myl ène Gerritsen, Laurens T. van der Meer, Owen Williams, Peter M. Hoogerbrugge, Blanca Scheijen, Frank N. van Leeuwen Tags: Brief Communications Source Type: research