Prostate cancer is now a bigger killer than breast cancer

More than 11,800 men a year are now killed by the disease in Britain, compared with about 11,400 women dying of breast cancer, placing the disease as the third biggest cancer killer.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news

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Conclusion: TRPV6 mRNA and protein are elevated in biopsies of ovarian cancers compared to normal tissue. Inhibition of TRPV6 activity significantly reduces ovarian tumour growth providing evidence that TRPV6 is a feasible oncology target in ovarian cancers.
Source: Journal of Cancer - Category: Cancer & Oncology Authors: Tags: Research Paper Source Type: research
Background: Accurate histopathological evaluation of lymph nodes (LNs) is essential for reliable staging in prostate cancer. In routine practice, conventional techniques only examine parts of the LN. Molecular nodal staging methods are limited by their high costs and extensive time requirement. One-step nucleic acid amplification (OSNA) determines the metastatic status of the complete LN and allows for rapid intraoperative detection of LN metastases. OSNA has been proposed for diagnosis of LN metastases from breast cancer by quantifying the CK19 mRNA copy number. To provide basic data for OSNA development for prostate canc...
Source: Journal of Cancer - Category: Cancer & Oncology Authors: Tags: Research Paper Source Type: research
CONCLUSIONS: Our preliminary data demonstrate that ozone therapy is a valid supportive therapy for fatigue in cancer patients, both during cancer therapy and in a palliative setting with no significant side effects. PMID: 30536352 [PubMed - in process]
Source: European Review for Medical and Pharmacological Sciences - Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research
Abstract Steroid receptor coactivator 1 (SRC-1) is a transcriptional coactivator for steroid receptors and other transcription factors. SRC-1 has been shown to play an important role in the progression of breast cancer and prostate cancer. However, its role in glioma progression remains unknown. Here, in this study, we reported that SRC-1 is upregulated in the vessels of human glioma and exerts important regulatory functions. Specifically, SRC-1 expression significantly enhanced bFGF-mediated angiogenesis in vivo. Downregulating of SRC-1 expression suppressed endothelial cell migration and tube formation in vitro ...
Source: Biochemistry and Cell Biology - Category: Biochemistry Authors: Tags: Biochem Cell Biol Source Type: research
BOSTON (CBS) – Alex Fitzpatrick went from Hollywood screenwriter to Massachusetts restaurant owner so she and her husband could spend more time with her children. When she recently found out her risk of getting breast cancer was as high as 80%, all she could think of was her three boys. “I do want to make sure that I’m the one telling them what to wear on their wedding day and watch them go to college,” she said. Alex has one of the BRCA gene mutations. She got tested when an aunt was recently diagnosed with an aggressive form of breast cancer. “I was blindsided to be honest,” she remem...
Source: WBZ-TV - Breaking News, Weather and Sports for Boston, Worcester and New Hampshire - Category: Consumer Health News Authors: Tags: Boston News Health Syndicated Local Watch Listen Angelina Jolie Breast Cancer Dr. Mallika Marshall Mass General Hospital Source Type: news
AbstractData regarding cancer risk for individuals who were exposed to traumatic and stressful life events are conflicting. We sought to evaluate the association between posttraumatic stress disorder (PTSD) and the risk of the four most common solid tumors: lung, breast, prostate, and colorectal cancers. We conducted four nested case ‐control studies using a large UK population‐based database. Cases were defined as individuals with any medical code for the specific malignancy. For every case, we used incidence‐density sampling to match four controls by age, sex, practice site, and both duration and calendar time of f...
Source: Journal of Traumatic Stress - Category: Psychiatry & Psychology Authors: Tags: Research Article Source Type: research
Radiation oncologist Dr. Andrea McKee believes deaths from lung cancer — including those related to asbestos exposure — could be reduced significantly by increased utilization of early CT screening. McKee, chair of radiation oncology at Lahey Hospital and Medical Center in Burlington, Maine, has been a strong proponent of early screening for several years. “We could be saving tens of thousands of lives every year with this,” McKee told The Mesothelioma Center at “There is nothing else like it. The life-saving potential is the most important thing that has happened to cancer in my...
Source: Asbestos and Mesothelioma News - Category: Environmental Health Authors: Source Type: news
Abstract Long non-coding RNAs (lncRNAs) have been found essential for tumorigenesis of prostate cancer (PC), but its role in the regulation of castration-resistant prostate cancer (CRPC) is poorly identified. Here, we showed that a lncRNA, Breast-Cancer Anti-Estrogen Resistance 4 (BCAR4), which plays a pivotal role in the tamoxifen-resistance of breast cancer, was significantly upregulated in CRPC, but not in castration-sensitive prostate cancer (CSPC), compared to normal prostate tissue. High BCAR4 levels in CRPC were correlated with poor patients' overall survival. Androgen increased growth and migration of andr...
Source: Aging - Category: Biomedical Science Authors: Tags: Aging (Albany NY) Source Type: research
Abstract Adjuvant aromatase inhibitor therapy for hormone receptor-positive breast cancer in postmenopausal women, and gonadotropin-releasing hormone agonist for prostate cancer in men, are associated with bone loss, leading to the increment of fracture risks. Assessment of bone status, improvement of life style such as diet and exercise, and osteoporosis treatments are essential to keep good bone health in cancer treatment-induced bone loss. PMID: 30487333 [PubMed - in process]
Source: Clinical Genitourinary Cancer - Category: Cancer & Oncology Authors: Tags: Clin Calcium Source Type: research
This article summarizes the milestones in the development of talazoparib leading to its first approval for the treatment of adults with deleterious or suspected deleterious germlineBRCA-mutated, HER2-negative, locally advanced or metastatic breast cancer.
Source: Drugs - Category: Drugs & Pharmacology Source Type: research
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