Sanofi and partner seek European Medicines Agency review for sleep sickness product

PARIS (Reuters) - French healthcare group Sanofi, along with its business partner, has asked the European Medicines Agency (EMA) to review the fexinidazole product for the treatment of sleeping sickness, the company said on Wednesday.
Source: Reuters: Health - Category: Consumer Health News Tags: healthNews Source Type: news

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Authors: Buguet A, Gati Ouonkoye R, Bogui P, Cespuglio R Abstract Sleeping habits and morningness-eveningness questionnaires (chronotype), and polysomnography (internal sleep organization) were proposed to healthy volunteers living under natural climates from different locations in West Africa (Niger, Côte d'Ivoire) and Central Africa (Angola, Congo). Under the Sahelian dry climate, 138 Niger medical students (130 had afternoon naps) completed 1792 sleep questionnaires during 7-day sessions in the cool-dry and hot-dry seasons. As everywhere else on Earth, daily sleep lasted 7 to 8hours. In Abidjan (hot-humid ...
Source: Revue Neurologique - Category: Neurology Tags: Rev Neurol (Paris) Source Type: research
Abstract Sleep is frequently altered in systemic infections as a component of sickness behavior in response to inflammation. Sleepiness in sickness behavior has been extensively investigated. Much less attention has instead been devoted to sleep and wake alterations in brain infections. Most of these, as other neuroinfections, are prevalent in sub-Saharan Africa. The present overview highlights the importance of this topic from both the clinical and pathogenetic points of view. Vigilance states and their regulation are first summarized, emphasizing that key nodes in this distributed brain system can be targeted by...
Source: Brain Research Bulletin - Category: Neurology Authors: Tags: Brain Res Bull Source Type: research
Abstract In this review we describe how Trypanosoma brucei brucei, a rodent pathogenic strain of African trypanosomes, can invade the nervous system, first by localization to the choroid plexus, the circumventricular organs (CVOs) and peripheral ganglia, which have fenestrated vessels, followed by crossing of the blood-brain barrier (BBB) into the white matter, hypothalamus, thalamus and basal ganglia. White blood cells (WBCs) pave the way for the trypanosome neuroinvasion. Experiments with immune deficient mice show that the invasion of WBCs is initiated by the toll-like receptor 9, followed by an augmentation ph...
Source: Brain Research Bulletin - Category: Neurology Authors: Tags: Brain Res Bull Source Type: research
(UT Southwestern Medical Center) An international study from the O'Donnell Brain Institute shows one of Africa's most lethal diseases is actually a circadian rhythm disorder caused by the acceleration of biological clocks controlling a range of vital functions besides sleep.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news
Conclusions/SignificanceThe results show a modest increase inCxcl9 andCxcl11 transcripts in the brain and the emergence of sleep/wake cycle fragmentation in the initial encephalitic stage, followed by increases inIfn-γ and IFN-dependent chemokine transcripts in the brain and of CXCL10 in the cerebrospinal fluid. The latter parameter and sleep/wake alterations could provide combined humoral and functional biomarkers of the early encephalitic stage in African trypanosomiasis.
Source: PLoS Neglected Tropical Diseases - Category: Tropical Medicine Authors: Source Type: research
Narcolepsy is the most well-characterized hypersomnia in both clinical and basic research fields. Narcolepsy is caused by degeneration of hypocretin-producing neurons in the hypothalamus. Although hypocretin receptor antagonists have been developed as sleep-inducing drugs, a high dose of suvorexant, a hypocretin receptor antagonist, inhibits gene expression of prepro-hypocretin to induce narcoleptic attack in wild-type mice. Prostaglandin D2 is the most potent endogenous sleep-promoting substance. Overproduction of prostaglandin D2 is involved in hypersomnia in patients with mastocytosis and African sleeping sickness or in...
Source: Sleep Medicine Clinics - Category: Sleep Medicine Authors: Source Type: research
(Instituto de Medicina Molecular) Researchers from iMM Lisboa have shown that the parasite responsible for sleeping sickness, Trypanosoma brucei, has its own internal clock, which allows it to anticipate daytime alterations of its surrounding environment and become more virulent.
Source: EurekAlert! - Infectious and Emerging Diseases - Category: Infectious Diseases Source Type: news
This article is part of HuffPost’s Project Zero campaign, a yearlong series on neglected tropical diseases and efforts to fight them. Lying in a hospital bed at the State Department medical unit in Washington, D.C., Claude Reece suspected he might have contracted malaria. It was 1995 and the American was sent back to the U.S. after coming down with a fever, sweats, pounding stomach aches and headaches, while on his first assignment working as a USAID country desk officer for Chad. “I felt that whatever ailment I contracted could be treated by the Medical Unit,” Reece told The Huffington Post ― that...
Source: Healthy Living - The Huffington Post - Category: Consumer Health News Source Type: news
ConclusionThese findings demonstrate invasion of the neuropil over time, after an initial interval, by parasites and lymphocytes crossing the blood-brain barrier, and show that neurological features can precede this event. The data thus challenge the current clinical and cerebrospinal fluid criteria of disease staging.
Source: PLoS Neglected Tropical Diseases - Category: Tropical Medicine Authors: Source Type: research
This article is part HuffPost’s Project Zero campaign, a yearlong series on neglected tropical diseases and efforts to eliminate them. His name was Tendayi. He had watched five of his nine children die. Yet when he was diagnosed with a serious disease, he steadfastly held onto his will to live ― until he just couldn’t anymore.   Tendayi died about a decade ago, but his picture still sits on Dr. Wilfried Mutombo’s desk in Kinshasa, the capital of the Democratic Republic of Congo. It reminds him daily that a terrifying ― yet treatable ― disease is still killing far too many people. Muto...
Source: Healthy Living - The Huffington Post - Category: Consumer Health News Source Type: news
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