Defining B Cell Chromatin: Lessons from EBF1.

Defining B Cell Chromatin: Lessons from EBF1.
Trends Genet. 2018 Jan 11;:
Authors: Boller S, Li R, Grosschedl R
Abstract
Hematopoiesis is regulated by signals from the microenvironment, transcription factor networks, and changes of the epigenetic landscape. Transcription factors interact with and shape chromatin to allow for lineage- and cell type-specific changes in gene expression. During B lymphopoiesis, epigenetic regulation is observed in multilineage progenitors in which a specific chromatin context is established, at the onset of the B cell differentiation when early B cell factor 1 (EBF1) induces lineage-specific changes in chromatin, during V(D)J recombination and after antigen-driven activation of B cells and terminal differentiation. In this review, we discuss the epigenetic changes underlying B cell differentiation, focusing on the role of transcription factor EBF1 in B cell lineage priming.
PMID: 29336845 [PubMed - as supplied by publisher]

Source: Trends in Genetics : TIG - January 11, 2018 Category: Genetics & Stem Cells Authors: Boller S, Li R, Grosschedl R Tags: Trends Genet Source Type: research