Defining B Cell Chromatin: Lessons from EBF1

Publication date: Available online 11 January 2018 Source:Trends in Genetics Author(s): Sören Boller, Rui Li, Rudolf Grosschedl Hematopoiesis is regulated by signals from the microenvironment, transcription factor networks, and changes of the epigenetic landscape. Transcription factors interact with and shape chromatin to allow for lineage- and cell type-specific changes in gene expression. During B lymphopoiesis, epigenetic regulation is observed in multilineage progenitors in which a specific chromatin context is established, at the onset of the B cell differentiation when early B cell factor 1 (EBF1) induces lineage-specific changes in chromatin, during V(D)J recombination and after antigen-driven activation of B cells and terminal differentiation. In this review, we discuss the epigenetic changes underlying B cell differentiation, focusing on the role of transcription factor EBF1 in B cell lineage priming.

Source: Trends in Genetics - January 13, 2018 Category: Genetics & Stem Cells Source Type: research