PIK3CA C2 domain deletions hyperactivate phosphoinositide 3-kinase (PI3K), generate oncogene dependence and are exquisitely sensitive to PI3K α inhibitors.

CONCLUSIONS: C2 domain deletions in PIK3CA generate PI3K dependence and should be considered biomarkers of sensitivity to PI3K inhibitors.
PMID: 29284706 [PubMed - as supplied by publisher]

Source: Clinical Cancer Research - December 28, 2017 Category: Cancer & Oncology Authors: Croessmann S, Sheehan JH, Lee KM, Sliwoski GR, He J, Nagy RJ, Riddle DA, Mayer IA, Balko JM, Lanman RB, Miller V, Cantley LC, Meiler J, Arteaga CL Tags: Clin Cancer Res Source Type: research