Technology: New method for endogenous protein degradation
Nature Reviews Drug Discovery 17, 18 (2018).
doi:10.1038/nrd.2017.260
Author: Sarah Crunkhorn
Current strategies to modulate protein expression rely on DNA knock out or RNA interference. A novel method — Trim-Away — can directly and rapidly degrade endogenous proteins in mammalian cells, minimizing the risk of phenotype compensation and off-target effects. Trim-Away introduces exogenous TRIM21 (an E3
Source: Nature Reviews Drug Discovery - Category: Drugs & Pharmacology Authors: Sarah Crunkhorn Tags: Research Highlight Source Type: research
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