Technology: New method for endogenous protein degradation

Nature Reviews Drug Discovery 17, 18 (2018). doi:10.1038/nrd.2017.260 Author: Sarah Crunkhorn Current strategies to modulate protein expression rely on DNA knock out or RNA interference. A novel method — Trim-Away — can directly and rapidly degrade endogenous proteins in mammalian cells, minimizing the risk of phenotype compensation and off-target effects. Trim-Away introduces exogenous TRIM21 (an E3
Source: Nature Reviews Drug Discovery - Category: Drugs & Pharmacology Authors: Tags: Research Highlight Source Type: research