Bone Deficits Seen at Distal Tibia in Adults With Cystic Fibrosis Bone Deficits Seen at Distal Tibia in Adults With Cystic Fibrosis

Adult patients with cystic fibrosis (CF) have decreased volumetric bone mineral density (vBMD) and stiffness in the distal tibia, compared with healthy individuals, according to new research.Reuters Health Information
Source: Medscape Orthopaedics Headlines - Category: Orthopaedics Tags: Diabetes & Endocrinology News Source Type: news

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Publication date: Available online 23 November 2018Source: Canadian Journal of DiabetesAuthor(s): Valérie Boudreau, Quitterie Reynaud, Anne Bonhoure, Isabelle Durieu, Rémi Rabasa-Lhoret
Source: Canadian Journal of Diabetes - Category: Endocrinology Source Type: research
Conference abstracts
Source: The Aspergillus Website - updates - Category: Respiratory Medicine Authors: Source Type: news
Conclusions: Asthma was associated to bronchiectasis in 76% of the patients but it was estimated as etiology in only every fifth patient. However, retrospectively it is difficult to exclude asthma as a background cause in many cases with recurrent asthma like symptoms and respiratory infections. Nevertheless, in one fifth of the patients no identifiable cause was found. None of the patients had had tuberculosis. Lung function test results were well preserved and in 66% bronchiectasis was restricted to one-three lobes.
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Epidemiology Source Type: research
Rationale: Although Cystic Fibrosis (CF) with residual function mutations (RFM) can be associated with less severe disease, no firm conclusions are available on long-term outcomes. Aim of the study was to investigate long-term outcomes in CF adults with ≥1 RFM.Methods: A secondary analysis of the Milan Adult CF Database was performed: it includes consecutively enrolled adults diagnosed following the 2017 CF Foundation guidelines. Patients were referred between 2006 and 2016 to the Adult CF Center of the Policlinico Hospital, Milan, Italy. Patients with ≥1 RFM (Group 1) and with F508del homozygosis or ≥1 class I mu...
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Cystic fibrosis Source Type: research
Rationale: Cystic fibrosis (CF) is a heterogeneous disease with most mutations resulting in defective or missing protein. However, some mutations permit a residual function. The present study aimed to assess disease severity and clinical features of CF adults with residual function mutation (RFM).Methods: A secondary analysis of the Milan Adult CF Database enrolling CF adults according to 2017 CF Foundation guidelines and followed up from 2006 to 2016 was conducted. Patients with ≥1 RFM (Group 1) and those with either F508del homozygosis or ≥1 class I mutation (Group 2) were selected.Results: Out of 325 patients, 69 ...
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Cystic fibrosis Source Type: research
This study aimed to investigate if sputum glucose was associated with clinical markers of lung disease severity in CF adults.Methods: This was an observational, prospective study of consecutive adults with CF enrolled at the Adult CF Center in Milan, Italy, between April and June 2017. Patients with a diagnosis of CF according to last guidelines underwent glucose evaluation on sputum during stable state and demographics, clinical and microbiological data were collected. Sputum glucose assay uses the glucose oxidase-peroxide reaction for the determination of glucose concentrations. CF-related diabetes (CFRD) was evaluated a...
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Cystic fibrosis Source Type: research
Conclusions: DR4 and DR11, which recognize the gene products of the HLA-DR B1 alleles, are the most prominent in the Iranian CF population and further research on should be conducted on DR4+ CF patients to understand the role in clinical phenotypes of CF.
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Cystic fibrosis Source Type: research
Conclusions: A minority of individuals with CF met guidelines for PA. Only a third with CFRD reported sufficient PA to meet guidelines. Further analysis of the impact of PA on the development of glucose intolerance (impaired GT and CFRD) may provide empirical evidence for providing advice on PA.
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Physiotherapists Source Type: research
Chronic conditions of childhood are common [1]. In Australia, asthma affects one in every 10 children, type one diabetes mellitus (T1DM) affects one in every 100 children, and cystic fibrosis (CF) affects 1 in every 2500 children [1,2]. Together, these three conditions impact the Australian population more than any other childhood chronic conditions (i.e., high social, health service resource and financial costs) [1,3]. With such high prevalence rates, it is almost inevitable that, over the course of a clinician ’s career, they will need to provide chronic condition self-management (CCSM) support to children.
Source: Patient Education and Counseling - Category: International Medicine & Public Health Authors: Source Type: research
Publication date: November 2018Source: Pharmacological Research, Volume 137Author(s): D. Visca, P. Pignatti, A. Spanevello, E. Lucini, E. La RoccaAbstractDiabetes is a common metabolic disorder affecting the entire body with high morbidity and mortality worldwide. The major complications related to diabetes are mostly due to the macrovascular and microvascular bed impairment due to metabolic, hemodynamic and inflammatory factors. However, studies over the past decades have added also the lung as a target organ in both type 1 and type 2 diabetes. Diabetes has always been addressed as a major comorbidity conditioning the dis...
Source: Pharmacological Research - Category: Drugs & Pharmacology Source Type: research
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