EU Gives Okay to Two Drugs for Rare Pediatric Endocrine Disorders EU Gives Okay to Two Drugs for Rare Pediatric Endocrine Disorders

Pediatric primary adrenal insufficiency and X-linked hypophosphatemia are rare and debilitating conditions for which current treatments are limited.Medscape Medical News
Source: Medscape Medical News Headlines - Category: Consumer Health News Tags: Diabetes & Endocrinology News Source Type: news

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Originally, a Trojan horse referred to the wooden horse used to cunningly penetrate and conquer the city of Troy by the Greeks. In our era, the term has been adapted to describe disguised malwares that attack unsuspecting users’ computers and wreak havoc once inside. Judging by the title of this article, how then can a condition as serious as diabetes help move the digital health agenda forward? Computer generated 3D illustration with the Trojan Horse at Troy, source: http://codingtidbit.com/ Once upon a time, empowered patients started a revolution…  It all begins with a crippling speed of bure...
Source: The Medical Futurist - Category: Information Technology Authors: Tags: E-Patients Future of Medicine Healthcare Design diabetes digital health diabetes management patient design Source Type: blogs
A new review provides insight into the genetics of primary adrenal insufficiency that can have implications for the management of this condition.Clinical Endocrinology
Source: Medscape Today Headlines - Category: Consumer Health News Tags: Diabetes & Endocrinology Journal Article Source Type: news
Purpose of review Adrenoleukodystrophy (ALD) is a peroxisomal disorder with varying clinical presentations, including adrenal insufficiency, neurologic disease, and testicular dysfunction. The present review is intended to describe the current knowledge of the pathophysiology of ALD and provide an update regarding newborn screening, diagnosis, monitoring, and treatment. Recent findings New York State initiated newborn screening for ALD on December 30, 2013. Successful ALD newborn screening has led to its addition on other state newborn screens and recommendations for universal screening. Initial incidence reports, bas...
Source: Current Opinion in Endocrinology, Diabetes and Obesity - Category: Endocrinology Tags: GROWTH AND DEVELOPMENT: Lynne L. Levitsky Source Type: research
A 49-year-old female with history of daily inhaled corticosteroid use for asthma presented to a concussion clinic 7 wk after sport-related head injury with headache, visual blurring, dizziness, nausea, fatigue, polydipsia, and polyuria. Examination revealed difficulty with vestibuloocculomotor testing due to nausea and visual straining. Cranial computed tomography/magnetic resonance imaging was unremarkable. Laboratory testing revealed critically low serum cortisol, hypernatremia, and urine studies suggesting diabetes insipidus. The patient was referred to the emergency department. Intravenous fluid resuscitation, corticos...
Source: Current Sports Medicine Reports - Category: Sports Medicine Tags: Case Report Source Type: research
Abstract A 49-year-old female with history of daily inhaled corticosteroid use for asthma presented to a concussion clinic 7 wk after sport-related head injury with headache, visual blurring, dizziness, nausea, fatigue, polydipsia, and polyuria. Examination revealed difficulty with vestibuloocculomotor testing due to nausea and visual straining. Cranial computed tomography/magnetic resonance imaging was unremarkable. Laboratory testing revealed critically low serum cortisol, hypernatremia, and urine studies suggesting diabetes insipidus. The patient was referred to the emergency department. Intravenous fluid resus...
Source: Current Sports Medicine Reports - Category: Sports Medicine Authors: Tags: Curr Sports Med Rep Source Type: research
Authors: Agrawal L, Bacal A, Jain S, Singh V, Emanuele N, Emanuele MA, Meah F Abstract Immune checkpoint inhibitors (ICPIs) are novel drugs in the field of oncology however carry the risk of immune related dermatologic, gastrointestinal, and endocrine side effects which can be fatal. These new innovative immunoregulatory drugs have intertwined the fields of oncology and endocrinology. CTLA-4 and PD-1 are co-inhibitory receptors on T cells that turn the T cell "off" when binding to receptors on APCs. Tumor cells can also carry receptors for CTLA- and PD-1. By rendering T cells inactive, tumor cells can eva...
Source: Postgraduate Medicine - Category: Internal Medicine Tags: Postgrad Med Source Type: research
We describe the presentation, management, and outcomes of patients with PM. SUBJECTS, MATERIALS, AND METHODS: We performed a retrospective review of patients diagnosed with PM at a single institution from 1996 to 2015. Eighty-five patients diagnosed with metastasis to the pituitary or sella turcica by pathology or based on a combination of neuroimaging and clinical findings were included. Univariate and multivariable Cox regressions evaluated associations between clinical factors and overall survival. RESULTS: The most frequent sites of primary malignancies resulting in PM were lung (26%) and breast (26%). Median...
Source: The Oncologist - Category: Cancer & Oncology Authors: Tags: Oncologist Source Type: research
Low-dose ACTH stimulation tests are commonly used to diagnose central adrenal insufficiency. What are the optimal times for testing cortisol levels?Journal of Clinical Endocrinology &Metabolism
Source: Medscape Today Headlines - Category: Consumer Health News Tags: Diabetes & Endocrinology Journal Article Source Type: news
AbstractTo protect sporting ethics and athletes ’ health, the World Anti-Doping Agency (WADA) produced the World Anti-Doping Code and The Prohibited List of substances and methods forbidden in sports. In accordance with the International Standards for Therapeutic Use Exemption (ISTUE), to avoid rule violations and sanctions, athletes affected b y different endocrine diseases and disorders (e.g., adrenal insufficiency, diabetes, male hypogonadisms, pituitary deficit, thyroid diseases, etc.) who need to use a prohibited substance for therapeutic reasons (e.g., medical treatments, surgical procedures, clinical diagnosti...
Source: Journal of Endocrinological Investigation - Category: Endocrinology Source Type: research
CONCLUSIONS: Fully endoscopic pituitary surgery resulted in improvement of pituitary gland function in a substantial minority of patients. The deficiency from which patients were most likely to recover was adrenal insufficiency. Overall rates of postoperative permanent diabetes insipidus were low. This study provides multicenter benchmark neuroendocrine clinical outcome data for the endoscopic technique. PMID: 31731279 [PubMed - as supplied by publisher]
Source: Journal of Neurosurgery - Category: Neurosurgery Authors: Tags: J Neurosurg Source Type: research
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