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Source: Transplantation Reviews - Category: Transplant Surgery Source Type: research

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A Houston hospital is replacing the surgical director of its renowned heart transplant programs with two veteran transplant surgeons and a veteran transplant program executive
Source: ABC News: Health - Category: Consumer Health News Tags: Health Source Type: news
A Houston hospital is replacing the surgical director of its renowned heart transplant programs with two veteran transplant surgeons and a veteran transplant program executive
Source: ABC News: Health - Category: Consumer Health News Tags: Health Source Type: news
Publication date: Available online 18 October 2018Source: IDCasesAuthor(s): Miriams Teresita Castro-Lainez, Miguel Sierra-Hoffman, Victoria Valladares, Tywaun Tillman, Oscar A. Iznaloa-Esquivel, Alan Howell, Robert Fader, Richard Winn, Chetan JinadathaAbstractTreatment of enterococcal endocarditis in patients with history of renal transplantation is complicated. Treatment failure and/or drug toxicities are not uncommon. Treatment with ampicillin and daptomycin in a renal transplant patient has been rarely reported. Here we report a patient who was successfully treated with this novel combination.
Source: IDCases - Category: Infectious Diseases Source Type: research
We report a case of a 50-year-old renal transplant female admitted with fever and malaise 3 months post-transplant and presenting anemia, fever, hypertriglyceridemia, high levels of serum ferritin, and positive CMV antigenemia. Urine was positive for decoy cells and BKV-DNA. Graft biopsy showed CMV nephritis. Both blood and urine cultures where positive for E. coli. Hemophagocytosis was confirmed by bone marrow aspiration. Immunosuppression was reduced, and the patient received high-dose intravenous immunoglobulin and dexamethasone, with complete response after 3 weeks. We highlight the importance of early diagnosis and pr...
Source: Jornal Brasileiro de Nefrologia - Category: Urology & Nephrology Tags: J Bras Nefrol Source Type: research
In this study, a feasible protocol for robust hematopoiesis has been elaborated. We achieved a significant increase of the teratoma-derived hematopoietic population when teratomas were generated in the NSGS mouse, which provides human cytokines, together with co-injection of human umbilical vein endothelial cells. Since little is known about hematopoiesis in teratomas, we addressed localization and clonality of the hematopoietic lineage. Our results indicate that early human hematopoiesis is closely reflected in teratoma formation, and thus highlight the value of this model.Graphical Abstract
Source: Stem Cell Reports - Category: Stem Cells Source Type: research
This study provides a therapeutic strategy for targeting asthma inflammation.Graphical Abstract
Source: Stem Cell Reports - Category: Stem Cells Source Type: research
Publication date: Available online 18 October 2018Source: NeuronAuthor(s): Young J. Kim, Sattar Khoshkhoo, Jan C. Frankowski, Bingyao Zhu, Saad Abbasi, Sunyoung Lee, Ye Emily Wu, Robert F. HuntSummaryConsiderable evidence suggests loss-of-function mutations in the chromatin remodeler CHD2 contribute to a broad spectrum of human neurodevelopmental disorders. However, it is unknown how CHD2 mutations lead to impaired brain function. Here we report mice with heterozygous mutations in Chd2 exhibit deficits in neuron proliferation and a shift in neuronal excitability that included divergent changes in excitatory and inhibitory ...
Source: Neuron - Category: Neuroscience Source Type: research
Abbott (NYSE:ABT) said today it won FDA approval for its HeartMate 3 left ventricular assist device, now approved as a destination therapy for patients with advanced heart failure. With the approval, the Chicago-based company said that the device can now be used in patients not eligible for a transplant as a life-long implant. “We partner with physicians to holistically develop therapies that benefit patients and achieve better outcomes. The unique design of the HeartMate 3 LVAD—with its Full MagLev technology—takes an established innovation and improves upon it in meaningful ways to help people with...
Source: Mass Device - Category: Medical Devices Authors: Tags: Cardiac Implants Cardiovascular Food & Drug Administration (FDA) Regulatory/Compliance Abbott Source Type: news
Condition:   Hematopoietic and Lymphoid Cell Neoplasm Interventions:   Radiation: Total-Body Irradiation;   Procedure: Donor Lymphocyte Infusion;   Drug: Cyclophosphamide;   Procedure: Allogeneic Hematopoietic Stem Cell Transplantation;   Drug: Tacrolimus;   Drug: Mycophenolate Mofetil Sponsor:   Sidney Kimmel Cancer Center at Thomas Jefferson University Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Condition:   Clostridium Difficile Infection Intervention:   Other: Faecal microbiota transplantation (FMT) Sponsor:   University of Aarhus Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
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