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Source: Transplantation Reviews - Category: Transplant Surgery Source Type: research

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In this study we performed mutagenicity, cytotoxic and transplacental evaluation of magnetic core mesoporous silica nanoparticles, radiolabeled with 99mTc for determination of toxicogenic and embryonic/fetuses potential risk in animal model. Magnetic core mesoporous silica nanoparticles were produced and characterized by obtaining nanoparticles with a size of (58.9 ± 8.1 nm) in spherical shape and with intact magnetic core. The 99 m Tc radiolabeling process demonstrated high efficacy and stability in 98% yield over a period of 8 hours of stability. Mutagenicity assays were performe...
Source: Artificial Cells, Nanomedicine and Biotechnology - Category: Biotechnology Tags: Artif Cells Nanomed Biotechnol Source Type: research
The finding by Remmler et  al1 that increased levels of interleukin 6 (IL6) predict 90-day and 1-year mortality in patients with end-stage liver disease is of high importance. In addition to its relevance for prognosis and timing of liver transplantation, we believe that the determination of IL6 levels could represent a pos sible target for therapy. Indeed, IL6 increases occur in autoimmune diseases, but more importantly is a consequence of infections. Viral causes of chronic liver diseases, such as hepatitis C and B viruses, now can be cured in a very high percentage of patients with the administration of antivirals.
Source: Clinical Gastroenterology and Hepatology - Category: Gastroenterology Authors: Tags: Letter to the Editor Source Type: research
Date: Wednesday, 05 23, 2018; Speaker: Ronald Gress, MD, Chief, Experimental Transplantation and , Immunology Branch and Head, Cytokine Biology Section, NCI; Christopher G. Kanakry, MD Assistant Clinical Investigator, , Experimental Transplantation and Immunology Branch and Head, Cytokine Biology Section, NCI; Building: Building 10 (Clinical Center); Lipsett Amphitheater; CME Credit; Videocast Event
Source: NIH Calendar of Events - Category: American Health Source Type: events
CONCLUSION: A patient with severe CDI and Hartmann rectal stump after hemicolectomy was treated with vancomycin. After oral vancomycin therapy, significant enteral absorption was observed, while levels stayed undetectable during intracolonic administration alone. PMID: 29691261 [PubMed - in process]
Source: American Journal of Health-System Pharmacy : AJHP - Category: Drugs & Pharmacology Authors: Tags: Am J Health Syst Pharm Source Type: research
MIT researchers have developed a device to keep implanted pancreatic islets oxygenated and alive. The technique involves a replenishable oxygen reservoir and a coating that protects the cells from the immune system. In tests in diabetic rats, the sub...
Source: Medgadget - Category: Medical Devices Authors: Tags: Genetics Materials Medicine Pediatrics Source Type: blogs
CONCLUSIONS: This study showed that NAC administration in deceased-donor KT recipients can reduce tubular kidney injury, evidenced by u-NGAL measurements. Improvement in early graft function needs a larger sample size to reach a statistical conclusion. PMID: 29683755 [PubMed - as supplied by publisher]
Source: Biomarkers - Category: Research Tags: Biomarkers Source Type: research
Functional bowel disorders (FBD) resemble a group of diseases of the gastrointestinal (GI) tract that are without a clear pathogenesis; the best known is probably the “irritable bowel syndrome” (IBS). Only recently we have been able to explore the role of the gut microbiota in FBD due to progress in microbiological analytic techniques. There are different ways to explore the role of the gut microbiota and its dysbiosis in FBD. Comparison of the microbial comp osition in a group of patients with FBD, for example, with IBS to a group of healthy volunteers is one way. Studies have shown that the microbiota in FBD ...
Source: Annals of Nutrition and Metabolism - Category: Nutrition Source Type: research
First generation stem cell therapies largely achieve their results through brief signaling changes, not through any lasting work on the part of the transplanted cells. Those cells in fact die quite rapidly, but the signals they secrete while still alive change the behavior of native cells. This produces benefits such as reduced inflammation or improved regenerative capacity. Given this, why not deliver the signals instead of the cells? It could in principle be an easier, less complex task. Much of cell signaling involves the exchange of extracellular vesicles, tiny membrane-bound packages of molecules. Numerous groups are ...
Source: Fight Aging! - Category: Research Authors: Tags: Daily News Source Type: blogs
Contributors : Hyun Park ; Mira Jeong ; Margaret Goodell ; Grant ChallenSeries Type : Methylation profiling by high throughput sequencingOrganism : Mus musculusRecent epidemiological studies have shown that cancer-associated DNMT3A mutations can be detected in the blood of a large proportion of asymptotic elderly individuals. It is important to understand how these mutations provide a competitive advantage to HSCs and allow them to establish clonal dominance. Here we demonstrate that the stress of serial HSC transplantation immortalizes Dnmt3a-null HSCs.
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Methylation profiling by high throughput sequencing Mus musculus Source Type: research
Contributors : Hyun Park ; Mira Jeong ; Margaret Goodell ; Grant ChallenSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Mus musculusRecent epidemiological studies have shown that cancer-associated DNMT3A mutations can be detected in the blood of a large proportion of asymptotic elderly individuals. It is important to understand how these mutations provide a competitive advantage to HSCs and allow them to establish clonal dominance. Here we demonstrate that the stress of serial HSC transplantation immortalizes Dnmt3a-null HSCs.
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Genome binding/occupancy profiling by high throughput sequencing Mus musculus Source Type: research
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