FDA approves diabetes drug that also helps with weight loss

The new therapy, a once-a-week shot, appears to be more effective than a popular daily diabetes pill, a study shows
Source: Health News: CBSNews.com - Category: Consumer Health News Source Type: news

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Publication date: Available online 21 October 2018Source: American Journal of Preventive MedicineAuthor(s): Soham Gupta, Alexander P. Cole, Maya Marchese, Ye Wang, Jacqueline M. Speed, Sean A. Fletcher, Junaid Nabi, Sebastian Berg, Stuart R. Lipsitz, Toni K. Choueiri, Steven L. Chang, Adam S. Kibel, Annemarie Uhlig, Quoc-Dien TrinhIntroductionWith improvements in early detection and treatment, a growing proportion of the population now lives with a personal history of a cancer. Although many cancer survivors are in excellent health, the underlying risk factors and side effects of cancer treatment increase the risk of medic...
Source: American Journal of Preventive Medicine - Category: International Medicine & Public Health Source Type: research
ConclusionsAlthough increasing, the rate of GP referral to exercise physiologists was low and associated with patient and GP characteristics. Education of GPs about the role of exercise physiologists in the prevention and management of chronic diseaseconditions is needed.
Source: Journal of Science and Medicine in Sport - Category: Sports Medicine Source Type: research
Publication date: November–December 2018Source: Spine Deformity, Volume 6, Issue 6Author(s): Jun S. Kim, Varun Arvind, Eric K. Oermann, Deepak Kaji, Will Ranson, Chierika Ukogu, Awais K. Hussain, John Caridi, Samuel K. ChoAbstractStudy DesignCross-sectional database study.ObjectiveTo train and validate machine learning models to identify risk factors for complications following surgery for adult spinal deformity (ASD).Summary of Background DataMachine learning models such as logistic regression (LR) and artificial neural networks (ANNs) are valuable tools for analyzing and interpreting large and complex data sets. AN...
Source: Spine Deformity - Category: Orthopaedics Source Type: research
Conclusions/interpretation: Circulating Pro-NT is not independently associated with GDM, but is with HOMA-IR, creatinine, and FFA even after adjustment for pregnancy status.
Source: Nutrition, Metabolism and Cardiovascular Diseases - Category: Nutrition Source Type: research
s P Abstract Besides providing the majority of ATP production in cells, mitochondria are also involved in many other cellular functions and are central for cellular stress signaling. Mitochondrial dysfunction induces not only inherited mitochondrial disorders but also contributes to neurodegenerative diseases, cancer, diabetes, and metabolic syndrome. The HSP60/HSP10 molecular chaperone complex facilitates folding of mitochondrial proteins and is thus an important factor for many mitochondrial functions. To model different degrees of oxidative stress and mitochondrial dysfunction we here describe a HEK293 derived ...
Source: Mol Biol Cell - Category: Molecular Biology Authors: Tags: Methods Mol Biol Source Type: research
In conclusion, combination of pro-angiogenic small molecule DFO and HSYA in hydrogel provides a promising strategy to productively promote diabetic wound healing as well as better the repair quality. PMID: 30338719 [PubMed - in process]
Source: Drug Delivery - Category: Drugs & Pharmacology Tags: Drug Deliv Source Type: research
Authors: Sharif K, Watad A, Coplan L, Amital H, Shoenfeld Y, Afek A Abstract INTRODUCTION: Type 1 diabetes mellitus (T1DM) is a chronic disease characterized by the destruction of insulin-producing β-cells of the pancreas. The current paradigm in this disease's etiopathogenesis points toward the interplay of genetic and environmental factors. Among the environmental variables, dietary factors, intestinal microbiota, toxins, and psychological stress have been implicated in disease onset. Areas covered: This review aims to investigate the relationship between psychological stress and T1DM by presenting evidence ...
Source: Expert Review of Clinical Immunology - Category: Allergy & Immunology Tags: Expert Rev Clin Immunol Source Type: research
Publication date: Available online 21 October 2018Source: Journal of Herbal MedicineAuthor(s): Ahmad Saedisomeolia, Motahereh Makhdoomi Arzati, Mina Abdolahi, Mohsen Sedighiyan, Alejandra Rangel, Gerald Muench, Meysam Zarezadeh, Arash Jafarieh, Niyaz Mohammadzadeh HonarvarAbstractDiabetes mellitus is considered a metabolic disorder characterized by high blood sugar. Active disease is associated with low grade chronic inflammation resulting from the enhanced release of inflammatory mediators such as interleukin (IL)-1 β, IL-6, induced nitric oxide synthase, and cyclooxygenase-2 enzymes that lead to insulin resistance a...
Source: Journal of Herbal Medicine - Category: Complementary Medicine Source Type: research
Publication date: Available online 21 October 2018Source: Nanomedicine: Nanotechnology, Biology and MedicineAuthor(s): Ryan M Pearson, Joseph R Podojil, Lonnie D Shea, Nicholas JC King, Stephen D Miller, Daniel R GettsAbstractAutoimmune diseases, such as celiac disease, multiple sclerosis, and type 1 diabetes, are leading causes of morbidity and mortality in the United States. In these disease states, immune regulatory mechanisms fail that result in T and B cell-mediated destruction of self-tissues. The known role of T cells in mediating autoimmune diseases has led to the emergence of numerous therapies aimed at inactivati...
Source: Nanomedicine: Nanotechnology, Biology and Medicine - Category: Nanotechnology Source Type: research
Long time readers know that I often write about exercise and fitness.  Over the past 3 years I have written often about Orange Theory Fitness.  OTF focuses on high intensity interval training (cardio) complemented by strength work.  Working out regularly makes me feel better in many ways, and I would do it for a variety of reason, but this new article adds even more fuel to my OTF fire.  Association of Cardiorespiratory Fitness With Long-term Mortality Among Adults Undergoing Exercise Treadmill Testing.   The article is free.  CNN has a great article explaining the study – ...
Source: DB's Medical Rants - Category: Internal Medicine Authors: Tags: Medical Rants Source Type: blogs
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