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FDA approves diabetes drug that also helps with weight loss

The new therapy, a once-a-week shot, appears to be more effective than a popular daily diabetes pill, a study shows
Source: Health News: CBSNews.com - Category: Consumer Health News Source Type: news

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Got questions about life with diabetes? So do we! That's why we offer our weekly diabetes advice column, Ask D'Mine, hosted by our snarky diabetes expert Wil Dubois, a veteran type 1 and diabetes author.This week, Wil helps out a struggling woma...
Source: Diabetes Mine - Category: Endocrinology Authors: Source Type: blogs
Source: International Journal of Tuberculosis and Lung Disease - Category: Respiratory Medicine Authors: Tags: STATE OF THE ART Source Type: research
CONCLUSION: Time to diagnosis of CN was shorter than previously reported, though the high rate of deformities still suggests a significant delay in diagnosis. Increased education of healthcare professionals and people with diabetes-related neuropathy is important to ensure early diagnosis and appropriate management to reduce deformities and complications. PMID: 29240741 [PubMed - in process]
Source: New Zealand Medical Journal - Category: General Medicine Tags: N Z Med J Source Type: research
Each year, MD+DI’s editors gather to choose which company should be named the Medtech Company of the Year, and it’s always a heated debate. This year, we named nine finalists, but the decision to crown Abbott as our 2017 Medtech Company of the Year was unanimous. Our readers, however, had a different opinion. While MD+DI’s editors chose Abbott for its ability to rise above challenges, Bigfoot Biomedical was the favorite among our readership. The Milpitas, CA-based firm is amalgamating other companies’ hardware plus its own software and algorithms to craft an artificial pancreas for patients with dia...
Source: MDDI - Category: Medical Devices Authors: Tags: Business Source Type: news
This article describes the case of a 70-year-old man with diabetes mellitus, end-stage renal disease, and peripheral arterial occlusive disease who presented with a 1.5% total-body-surface-area, third-degree burn to the left hallux with dry gangrene extending to the midfoot. Ankle brachial indexes were 0.66 on the left and 0.64 on the right. Toe pressures on the left were absent because of extensive dry gangrene. His right foot had a prior transmetatarsal amputation. Using a retrograde pedal approach, a chronic total occlusion of the left posterior tibial artery was recanalized with balloon angioplasty. He then underwent a...
Source: Advances in Skin and Wound Care - Category: Dermatology Tags: Features: Case Report Source Type: research
Conclusion: In a cross-sectional study of U.S. adults, we observed some positive associations of uAs and toenail As concentrations with biomarkers potentially relevant to CVD pathogenesis and inflammation, and evidence of a higher capacity to metabolize inorganic As was negatively associated with a marker of oxidative stress. https://doi.org/10.1289/EHP2062 Received: 14 April 2017 Revised: 13 November 2017 Accepted: 15 November 2017 Published: 15 December 2017 Address correspondence to S.F. Farzan, 2001 N. Soto St., Los Angeles, CA, 90032. Telephone: (323)-442-5101; Email: sffarzan@usc.edu Supplemental Material is ava...
Source: EHP Research - Category: Environmental Health Authors: Tags: Research Source Type: research
Publication date: Available online 6 December 2017 Source:Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids Author(s): Makoto Kurano, Koji Hasegawa, Motoei Kunimi, Masumi Hara, Yutaka Yatomi, Tamio Teramoto, Kazuhisa Tsukamoto The physiological roles of phytosterols in chronic inflammation, which are believed to be involved in the underlying mechanisms for metabolic diseases, have yet to be elucidated. Therefore, in the present study, we aimed to elucidate the physiological roles of phytosterols in both clinical studies and animal experiments. We observed the existence of rather specific negative ...
Source: Biochimica et Biophysica Acta (BBA) Molecular and Cell Biology of Lipids - Category: Lipidology Source Type: research
Publication date: 12 December 2017 Source:Cell Reports, Volume 21, Issue 11 Author(s): Anthony R. Soltis, Norman J. Kennedy, Xiaofeng Xin, Feng Zhou, Scott B. Ficarro, Yoon Sing Yap, Bryan J. Matthews, Douglas A. Lauffenburger, Forest M. White, Jarrod A. Marto, Roger J. Davis, Ernest Fraenkel Obesity is a major human health crisis that promotes insulin resistance and, ultimately, type 2 diabetes. The molecular mechanisms that mediate this response occur across many highly complex biological regulatory levels that are incompletely understood. Here, we present a comprehensive molecular systems biology study of hepatic respo...
Source: Cell Reports - Category: Cytology Source Type: research
AbstractNonalcoholic fatty liver disease (NAFLD) is the most prevalent liver disease worldwide, and there is no approved pharmacotherapy. The efficacy of vitamin E and pioglitazone has been established in nonalcoholic steatohepatitis (NASH), a progressive form of NAFLD. GLP-1RA and SGLT2 inhibitors, which are currently approved for use in diabetes, have shown early efficacy in NASH, and also have beneficial cardiovascular or renal effects. Innovative NASH therapies include four main pathways. The first approach is targeting hepatic fat accumulation. Medications in this approach include modulation of peroxisome proliferator...
Source: Journal of Gastroenterology - Category: Gastroenterology Source Type: research
Publication date: Available online 14 December 2017 Source:Trends in Endocrinology & Metabolism Author(s): Luc Rochette, Marianne Zeller, Yves Cottin, Catherine Vergely In patients with diabetes, the hyperglycemia-driven excess generation of reactive oxygen species (ROS) induces oxidative stress (OS) in a variety of tissues. OS is closely associated with chronic inflammation and has a key role in the pathogenesis of vascular complications. The enzymes that generate ROS and gasotransmitters are redox regulated and are implicated in cellular signaling. As a result of cellular metabolism, cells produce significant amount...
Source: Trends in Endocrinology and Metabolism - Category: Endocrinology Source Type: research
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