Successive alkylation of PtII by RI to form bis-organoplatinum(IV) derivatives as key steps for cross-electrophile coupling

Publication date: Available online 2 December 2017 Source:Journal of Organometallic Chemistry Author(s): Oleg V. Khazipov, Tatyana V. Krasnyakova, Denis V. Nikitenko, Marina A. Merzlikina, Ekaterina V. Khomutova, Serge A. Mitchenko A solvent-specific reduction of PtIV iodo complexes into PtII by iodide ions was found: in acetone, PtIV iodo complexes are almost quantitatively reduced into PtII, and iodine, which is formed upon the reduction, is bound in a poorly soluble polymeric complex with NaI and acetone. The revealed solvent-specific reduction of PtIV into PtII was used for sequential alkylation of PtII iodo complexes with iodoacetone to form mono-, bis-, and tris-acetonyl PtIV derivatives and also with iodoacetic acid to give mono- and bis-carboxymethyl PtIV complexes. The reaction of iodoacetic acid is accompanied by its catalytic reduction into acetic acid. The organic ligands in the formed organoplatinum compounds are mutually cis, which is essential for further accomplishment of C-C coupling reactions. Graphical abstract
Source: Journal of Organometallic Chemistry - Category: Chemistry Source Type: research