Sparc expression in airway smooth muscle cells is regulated by the unfolded protein response and may be diminished in chronic obstructive pulmonary disease

Source: Respirology - Category: Respiratory Medicine Tags: COPD 2 Source Type: research

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Authors: Kuluöztürk M, Deveci F Abstract Aim: To determine of the prognostic value of Glasgow Prognostic Score (GPS) in acute exacerbation of Chronic Obstructive Pulmonary Disease (AECOPD) requiring hospitalization.Methods: Hospital electronic database of 129 patients with AECOPD was retrospectively searched and CRP levels, complete blood count, arterial blood gas (ABG) values and pulmonary function test (PFT) parameters of patients were recorded. Hospital mortality and need for ICU transfer were determined as adverse outcomes from files of cases.Results: 106 of 129 patients were male (82.2%) and rest of ...
Source: Expert Review of Respiratory Medicine - Category: Respiratory Medicine Tags: Expert Rev Respir Med Source Type: research
Chronic Obstructive Pulmonary Disease (COPD) will become the 3rd leading cause of death worldwide in 2020 and is currently the 3rd leading cause of hospital readmissions in the US. In October 2014, the Centers for Medicare and Medicaid Services (CMS) introduced penalties followed by bundle payments for care improvement initiates in patients hospitalized with an acute exacerbation of COPD (AECOPD). Fragmented care across settings cause readmissions for COPD. A patient-tailored case management initiative mitigated 30-day hospital readmissions at Sub-Acute Rehabilitation (SAR) centers.
Source: Journal of the American Medical Directors Association - Category: Health Management Authors: Source Type: research
Even patients with mild COPD exacerbations can benefit from antibiotics and systemic corticosteroids, a systematic review and meta-analysis suggests.Medscape Medical News
Source: Medscape FamilyMedicine Headlines - Category: Primary Care Tags: Pulmonary Medicine News Source Type: news
Chronic obstructive pulmonary disease (COPD) is a leading cause of death with a considerable part of the population dying from cardiovascular diseases. High-sensitivity troponin I (hs-TnI) might help to better identify COPD patients at high risk of mortality. We aimed to study the predictive value of hs-TnI for all-cause mortality beyond established COPD assessments, and after consideration of relevant cardiovascular risk factors and prevalent cardiovascular diseases, in a broad population with stable COPD. Circulating hs-TnI concentrations together with a wide range of respiratory and cardiovascular markers were evaluated...
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: COPD and smoking Original Articles: COPD Source Type: research
COPD is a leading cause of death in the world. COPD represents the pulmonary component of multimorbidity, often with cardiovascular disease (CVD) as the most prevalent, and possibly the most clinically relevant [1]. Indeed, cardiovascular diseases affect quality of life and healthcare costs, and are a major cause of death in COPD [2, 3]. The Global Initiative for Chronic Obstructive Lung Disease (GOLD) initiative recognises CVD as the most important disease coexisting with COPD and suggests it should be routinely looked for, suggesting the use of a CVD risk calculator [4].
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Editorials Source Type: research
AbstractChronic obstructive pulmonary disease (COPD) is one of the most important factors in the progress of cardiovascular disease (CVD) which is associated with limited airflow and alveolar demolition. The aim of this study is to investigate the possible protective effect of ellagic acid (EA), as a natural anti-oxidant, against pulmonary arterial hypertension (PAH) and development of lung and heart injuries induced by elastase. Sixty healthy male Sprague-Dawley rats (150 –180 g) were divided into six groups: control (saline 0.9%, 1 ml/kg, by gavage), porcinepancreatic elastase (PPE) (25  UI/kg, intra...
Source: Inflammation - Category: Allergy & Immunology Source Type: research
Shruti Singh, Sara Z Khan, Dilbagh Singh, Sameer Verma, Arunabh TalwarLung India 2020 37(2):151-157 Overnight pulse oximetry (OPO) has proven to be an effective and beneficial technique to determine the cardiorespiratory status of patients in both the inpatient and outpatient settings. It is a cheap, safe, reliable, simple, and accurate method of patient monitoring as compared to the expensive and labor-intensive method of multichannel polysomnography for detecting sleep-disordered breathing. It provides accurate information about patient's oxygenation status and also helps in monitoring the response to continuous pos...
Source: Lung India - Category: Respiratory Medicine Authors: Source Type: research
Conference abstracts
Source: The Aspergillus Website - updates - Category: Respiratory Medicine Authors: Source Type: news
By JESSICA DaMASSA, WTF HEALTH With a holistic mind-body approach to treating chronic back pain and COPD, Kaia Health is a digital therapeutics startup gaining a lot of attention from some really big players, including Optum Ventures (the venture arm of U.S. health insurance giant United Healthcare) which recently made an $8M follow-on investment to the startup’s Series A. What makes Kaia standout in a crowded field of digital health solutions focused on chronic pain? CEO Konstantin Mehl points to their proprietary tech, which uses a smartphone camera to provide real-time corrections to patients as they complete t...
Source: The Health Care Blog - Category: Consumer Health News Authors: Tags: Health Tech Health Technology Jessica DaMassa Start-Ups WTF Health COPD Kaia Health Source Type: blogs
Authors: Manavi KR, Alston-Mills BP, Thompson MP Abstract Tobacco usage kills more than 8 million people a year. Approximately 7 million of those deaths are the result of direct tobacco use, while approximately 1.2 million are the result of non-smokers being exposed to second-hand smoke. About 200 million of the world's one billion smokers are women and usage among women is increasing in some countries. Nicotine from smoking tobacco, specifically its metabolite cotinine, has negative effects on human health causing lung cancer, COPD and non-respiratory problems. Over a billion people worldwide are Vitamin D defici...
Source: International Journal for Vitamin and Nutrition Research - Category: Nutrition Tags: Int J Vitam Nutr Res Source Type: research
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