MiRNA-223 functions as both prognostic biomarker and tumor suppressor in mantle cell lymphoma through targeting SOX11

• MiRNA-223 is repressed and predicts a poorer clinical outcome in MCL patients.• MiRNA-223 suppresses cell proliferation and induces apoptosis of MCL cells.• MiRNA-223 is a repressor of SOX11, targeting the regulatory miRNA-223/SOX11 interaction.

Source: Experimental Hematology - November 20, 2017 Category: Hematology Authors: Keshu Zhou, Xiaoyan Feng, Yanying Wang, Yanyan Liu, Long Tian, Wenli Zuo, Shuhua Yi, Xudong Wei, Yongping Song, Lugui Qiu Tags: Review Source Type: research