{beta}7 integrins are required to give rise to intestinal mononuclear phagocytes with tolerogenic potential

Conclusions
Mice lacking β7 integrins in the innate immune compartment are more susceptible to intestinal inflammation, which is correlated with a requirement of β7 integrins to reconstitute gut mononuclear phagocytes with tolerogenic potential.

Source: Gut - August 3, 2014 Category: Gastroenterology Authors: Villablanca, E. J., De Calisto, J., Torregrosa Paredes, P., Cassani, B., Nguyen, D. D., Gabrielsson, S., Mora, J. R. Tags: Gut immunity Source Type: research