Upregulation of epidermal gap junctional proteins in patients with venous disease.

CONCLUSION: Connexins were overexpressed in patients with simple varicose veins, with a stepwise increased expression through venous eczema to ulceration. Connexin 43 is a potential biomarker for venous disease. This finding suggests that varicose veins predispose skin to poor wound healing. Surgical relevance The overexpression of connexins, a family of gap junctional proteins, is known to cause poor healing in venous leg ulceration. It is not known whether there is any association with superficial venous disease. Here, connexin proteins were overexpressed in patients with uncomplicated varicose veins, before histological skin changes. Connexin could be a biomarker of venous disease progression. PMID: 29143961 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/29143961?dopt=Abstract

Source: The British Journal of Surgery - November 16, 2017 Category: Surgery Authors: Kanapathy M, Simpson R, Madden L, Thrasivoulou C, Mosahebi A, Becker DL, Richards T Tags: Br J Surg Source Type: research